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2.A.3.8.7
y+LAT1 (transports neutral amino acids (i.e., Leu) in symport with Na+, Li+ or H+ in 1:1 stoichiometry; transports basic amino acids (i.e., Lys) by facilitated diffusion without a symported cation). Also transports the neurotoxicant, methylmercury-L-cysteine by molecular mimicry. Causes the Lysinuric protein intolerance condition in humans (Q9UM01) (Broer, 2008).

Accession Number:Q9R0S5
Protein Name:Y+L amino acid transporter 1
Length:512
Molecular Weight:55641.00
Species: [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Amino acids, Na+, Li+, H+, methylmercury-L-cysteine

Cross database links:

Genevestigator: Q9R0S5
eggNOG: roNOG11125
RefSeq: NP_112631.1   
Entrez Gene ID: 83509   
Pfam: PF00324   
KEGG: rno:83509   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (2)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.”  Pfeiffer R.et.al.   9878049

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MVASTKYEVA AQNEADEADG SAQGDGAGPA AEQVKLKKEI SLLNGVCLIV GNMIGSGIFV 
61:	SPKGVLMYSA SFGLSLVIWA VGGIFSVFGA LCYAELGTTI KKSGASYAYI LEAFGGFLAF 
121:	IRLWTSLLII EPTSQAVIAI TFANYMVQPL FPSCGAPYAA GRLLAAACIC LLTFINCAYV 
181:	KWGTLVQDIF TYAKVLALIA VIIAGIVRLG QGATTNFEDS FEGSSFAMGD IALALYSALF 
241:	SYSGWDTLNY VTEEIRNPER NLPLSIGISM PIVTIIYLLT NVAYYSVLDI KDILASDAVA 
301:	VTFADQIFGI FNWTIPLAVA LSCFGGLNAS IVAASRLLFV GSREGHLPDA ICMIHVERFT 
361:	PVPSLLFNGI LALVYLCVED IFQLINYYSF SYWFFVGLSI VGQLYLRWKE PDRPRPLKLS 
421:	LFFPIVFCLC TIFLVAVPLY SDTINSLIGI GIALSGLPFY FLIIRVPEHK RPLCLRRIVA 
481:	STTRYLQIIC MSVAAEMDLE DGELPKQGPK SK