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2.A.3.8.9
Heteromeric amino acid transporter #1 (transports most neutral aas with highest rates for Ala and Ser (Km≈100 μM)). They function by obligatory aa:aa exchange (Veljkovic et al., 2004b).

Accession Number:Q19834
Protein Name:AAT-1
Length:493
Molecular Weight:53804.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Amino acids

Cross database links:

eggNOG: meNOG06005
HEGENOM: HBG714539
RefSeq: NP_501707.1   
Entrez Gene ID: 177793   
Pfam: PF00324   
KEGG: cel:F27C8.1   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015171 F:amino acid transmembrane transporter activity
GO:0006865 P:amino acid transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTAEKEPLKS REGDEAPQNE TEGKGKGLEK SLTLFNGVSM IVGCIIGSGI FVSPTGVQEQ 
61:	AGSVGLSLIV WLISGIFTAI GAYCYAELGT LIKKSGGDYA YIMEAFGPFV AFIRLWIEAI 
121:	VVRPCTVTIV ALTFAIYGLR PFFPDCAPPD VVAELLAILL IVLMTAINCI SVRLATIVQD 
181:	WFTIAKVVAL CLIILTGLGL LFFGESQYKD SFENIFENTS QDFTKVSLAF YSGLFAYSGW 
241:	NFLNFIVEEL QNPKRNLPLA IAISITSCTV IYVLTNVALY TAISPDEMLE SPAVAVLFAN 
301:	KLYGKFAFIM PLCVACSTIG SANGVIFTSA RLFYSGAREG QMPAVLTMIN KKTKTPIPAV 
361:	ILTGALSIAY LLASKDVYQL INYIQISYWL AIGTAIAALF WLRRTMPDAS RPIKVPLIWP 
421:	AIFLAGCIAL VLIPMVAAPR DTGIGLLIML SAVPVYGIFI GWKNKPKWFN EFIDSSTVFI 
481:	QKLFMVVDED KED