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2.A.30.1.13
KCl symporter, KCC1. Water can be cotransported with KCl (Mollajew et al., 2010).

Accession Number:Q63632
Protein Name:SLC12A4 or KCC1
Length:1085
Molecular Weight:120628.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: Q63632
eggNOG: maNOG18449
RefSeq: NP_062102.1   
Entrez Gene ID: 29501   
Pfam: PF00324    PF03522   
KEGG: rno:29501   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015377 F:cation:chloride symporter activity
GO:0006821 P:chloride transport
GO:0006813 P:potassium ion transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.”  Gillen C.M.et.al.   8663127
[2] “Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.”  Su W.et.al.   10564083

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MPHFTVVPVD GPRRGDYDNL EGLSWVDYGE RAEREDSDGQ GNHRENSPFL SPLDASRGND 
61:	YYDRNLALFE EELDIRPKVS SLLGKLVSYT NLTQGAKEHE EAESGEGGRR RAAKAPSMGT 
121:	LMGVYLPCLQ NIFGVILFLR LTWMVGTAGV LQALLIVLIC CCCTLLTAIS MSAIATNGVV 
181:	PAGGSYFMIS RSLGPEFGGA VGLCFYLGTT FAAAMYILGA IEILLTYIAP PAAIFYPSGT 
241:	HDMSSATLNN MRVYGTIFLT FMTLVVFVGV KYVNKFASLF LACVIISILS IYVGGIKSAF 
301:	DPPVFPVCML GNRTLSRDQF DICAKTVVVD NETVATRLWT FFCHSPNLTA DSCDPYFLLN 
361:	NVTEIPGIPG AAAGVLQENL WSAYLEKGEV VEKHGLPSTD TLGLKESLSL YVVADIATSF 
421:	TVLVGIFFPS VTGIMAGSNR SGDLRDAQKS IPVGTILAIV TTSLVYFSSV ILFGACIEGV 
481:	VLRDKYGDGV SRNLVVGTLA WPSPWVIVVG SFFSTCGAGL QSLTGAPRLL QAIAKDNIIP 
541:	FLRVFGHGKA NGEPTWALLL TALIAELGIL IASLDMVAPI LSMFFLMCYL FVNLACAVQT 
601:	LLRTPNWRPR FKYYHWALSF LGMSLCLALM FVSSWYYALV AMVIAGMIYK YIEYQGAEKE 
661:	WGDGIRGLSL SAARYALLRL EEGPPHTKNW RPQLLVLLKL DEDLHVKYPR LLTFASQLKA 
721:	GKGLTIVGSV IQGSFLESYG EAQAAEQTIK NMMEIEKVKG FCQVVVASKV REGLAHLIQS 
781:	CGLGGMRHNS VVLGWPYGWR QSEDPRAWKT FIDTVRCTTA AHLALLVPKN IAFYPSNHER 
841:	YLEGHIDVWW IVHDGGMLML LPFLLRQHKV WKKCRMRIFT VAQMDDNSIQ MKKDLAIFLY 
901:	HLRLEAEVEV VEMHNSDISA YTYERTLMME QRSQMLRQMR LTKTERDREA QLVKDRHSAL 
961:	RLESLYSDEE DESVTGADKI QMTWTRDKYM AEPWDPSHAP DNFRELVHIK PDQSNVRRMH 
1021:	TAVKLNEVIV TRSHDARLVL LNMPGPPKNS EGDENYMEFL EVLTEGLERV LLVRGGGREV 
1081:	ITIYS