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2.A.30.1.5
NaCl/KCl symporter

Accession Number:P55013
Protein Name:NKC1 aka SLC12A2 or NKCC1
Length:1191
Molecular Weight:129775.00
Species:Squalus acanthias (Spiny dogfish) [7797]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Pfam: PF00324    PF08403   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015377 F:cation:chloride symporter activity
GO:0006821 P:chloride transport
GO:0006813 P:potassium ion transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Molecular cloning and functional expression of the bumetanide-sensitive Na-K-Cl cotransporter.”  Xu J.-C.et.al.   8134373

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEPAFPASSA GVQSQSGPEP GAGQQEPPPP ATPLRPVASQ SRFQVDLVTE GGGGGDGQKG 
61:	QTAAQPAAAA KDKDRGDGGA AAPSPASPAA AAEPPAAAAE EAKGRFRVNF VDPASDEPPL 
121:	SSQQQPPPPS SASSAHGGHQ PPSESMNGYP QNGDTMMSEG SLHSSGTGAH HYYDTHTNTY 
181:	YLRTFGHNTI DAVPRIDHYR HTVAQLGEKL IRPSLAELHD ELDKEPFEDG YVNGEESSPA 
241:	EEAVSKHVAD NKGVVKFGWI KGVLVRCMLN IWGVMLFIRL SWIVGHAGIG LALLVIGTAT 
301:	VVTTITGLST SAITTNGFVR GGGAYYLISR SLGPEFGGAI GLIFAFANAV AVAMYVVGFA 
361:	ETVRDLLVEH NALMIDEMSD IRIIGSVTIV VLFGISVAGM EWEAKAQIVL LGILLLAIVN 
421:	FTVGTFIPAN DKRAKGFFNY RGEIFSENFV PDFRDGEDFF SVFAIFFPAA TGILAGANIS 
481:	GDLADPQLAI PKGTLLAILI TTIVYAGAAV SVGSCIVREA TGNLTDAIIP GTVTNCTNVA 
541:	CKLGFNFSSC ATNKCSYGLM NDFQVMSLVS GFGPLITAGI FSATLSSALA SLVSAPKIFQ 
601:	ALCKDNIYPG LHVFSVGYGK NNEPLRGYVL TFFIGLGFIL IAELNVIAPI ISNFFLASYA 
661:	LINFSVFHAS LAKSPGWRPA FRFYNMWISL IGAILCCGVM FVINWWAALL TNVIVLALYI 
721:	YVTYKKPDVN WGSSTQALTY LNALQHAIRL TGVEDHVKNF RPQCLLMTGA PTSRPALLHL 
781:	VHAFTKNVGL VVCGHVHTGP RRQALKEIST DQAKYQRWLI KNKMKAFYAP VYAEDLREGT 
841:	QFLLQAVGLG RMRPNTLVFG FKKDWRQALM KDVENYINAI HDAFDYQYGV VVIRLKEGFN 
901:	ISHLQAQEEL CTSQEKSAHP KDIVVNLEHS DADSSKPSSK SVSETNSPAV CQDQKDEEDD 
961:	GKASTQPLLK KEVKDPSVPL NMTDQKLLQA SSQFQKKQGK GTIDVWWLFD DGGLTLLIPY 
1021:	LLTTKKKWKD CKIRVFIGGK INRIDHDRRT MATLLSKFRI DFSDITVLGD MNTKPSKDNI 
1081:	TAFEEMIEPF RLHEDDKEQE ASEKMKEEEP WRITDNELEI YRMKTYRQIR LNELLRENSG 
1141:	TANLIVMSLP VARKGAVSSA LYMAWIETLS KDLPPILLVR GNHQSVLTFY S