TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.30.1.8
Na+,K+,Cl--cotransporter, NKCC or Slc12a2, of 1120 aas and 12 TMSs.  Ion transport via an ortholog is oxygen-sensitive and is regulated by two different oxygen sensors in crucian carp (Carassius carassius) (Berenbrink et al. 2006).

Accession Number:C7EA90
Protein Name:Sodium-potassium-chloride cotransporter 1
Length:1120
Molecular Weight:122390.00
Species:Danio rerio (Zebrafish) [7955]
Number of TMSs:12
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSASPPISAG DYLSAPEPDA LKPAGPTPSQ SRFQVDLVTE SAGDGETTVG FDSSPPEYVA 
61:	EPPPDGLRDS VSGGEEAKGR FRVVNFAASS PDAAPAETAQ NGDTVMSEGS LHSSTGGQQH 
121:	HHYDTHTNTY YLRTFGHNTI DAVPKIDFYR QTAAPLGEKL IRPTLSELHD ELDKEPFEDG 
181:	FANGEELTPA EESAAKDVSE SKGVVKFGWI KGVLVRCMLN IWGVMLFIRM TWIVGQAGIA 
241:	YSCIIVIMAT VVTTITGCST SAIATNGFVR GGGAYYLISR SLGPEFGGSI GLIFAFANAV 
301:	AVAMYVVGFA ETVVELLMDS DLLMIDQTND IRVIGTITVI LLLGISVAGM EWEAKAQIFL 
361:	LVILITAIFN YFIGSFIAVD SKKKFGFFSY DAGILAENFG PDFRGQTFFS VFSIFFPAAT 
421:	GILAGANISG DLADPQMAIP KGTLLAILIT GLVYVGVAIS AGACIVRDAT GIESNFTLIS 
481:	NCTDAACKYG YDFSSCRPTV EGEVSSCKFG LHNDFQVMSV VSGFSPLISA GIFSATLSSA 
541:	LASLVSAPKV FQALCKDNIY PGIAIFGKGY GKNNEPLRGY FLTFGIALAF ILIAELNVIA 
601:	PIISNFFLAS YALINFSVFH ASLANSPGWR PSFKYYNMWA SLAGAILCCV VMFIINWWAA 
661:	LLTNVIVLSL YIYVSYKKPD VNWGSSTQAL TYHQALTHSL QLCGVADHIK TFRPQCLVMT 
721:	GAPNSRPAIL HLVHAFTKNV GLMLCGHVRI SSRRPNFKEL NSDMLRYQRW LLNNNSKAFY 
781:	TCVVAEDLRQ GTQYMLQAAG LGRLRPNTLV IGFKNDWRIG DIKEVETYIN LIHDAFDFQY 
841:	GVVILRLREG LDISHIQGQD DSSGMKDVVV SVDISKDSDG DSSKPSSKAT SVQNSPAVQK 
901:	DKKSPTVPLN VADQRLLDAS QQFQQKQGKG TVDVWWLFDD GGLTLLIPYL IANKKKWKDC 
961:	KIRVFIGGKI NRIDHDRRAM ATLLSKFRID FSDITVLGDI NTKPKSEGLT EFAEMIEPYK 
1021:	LREDDMEQEA AEKLKSEEPW RITDNELELY KAKGNRQIRL NELLKEHSST ANLIVMSMPL 
1081:	ARKGAVSSAL YMAWLDTLSK DLPPILLVRG NHQSVLTFYS