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2.A.30.1.9
Possible NaCl/KCl symporter

Accession Number:Q25479
Protein Name:NKCL
Length:1060
Molecular Weight:117393.00
Species:Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) [7130]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Pfam: PF00324   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015377 F:cation:chloride symporter activity
GO:0006821 P:chloride transport
GO:0006813 P:potassium ion transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Molecular cloning of a putative Na(+)-K(+)-2Cl-cotransporter from the Malpighian tubules of the tobacco hornworm, Manduca sexta.”  Reagan J.D.et.al.   7550244

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNDENRFNVS AVEGESKKNG IHMGANIITR PLRSSVENVE RGVAPNSQSE GWHHESGWKR 
61:	RRSLAQLTRE ALPRMENYRN SKRALKRPSL GELHGDHLIT EEDEKDQNHR DTKSPTPAVG 
121:	IKLGWIQGVF IPCLLNIWGV MLFLRLSWVV SQAGIGLSLV IIAISAIVCV ITTLSMSAIC 
181:	TNGEVKGGGI YYIISRSLGP EFGASVGIIF AFANAVAASM NTIGFCDSLN DLLRSNGLKI 
241:	TEDPINDVRI VGTVALLVMC IICAIGMDWE SKAQNFLIAI IVGAMVDFVV GTIMGPKDNS 
301:	EIAKGFVGLS SATFVENFKS DFRFSEKLDQ NFFSVFAIFF PSVTGIQAGA NISGDLKDPA 
361:	SAIPKGTLLA LLISMVSYTL MVLFAGGGAL RDASGNITDL LIVNGTVTDY SSVSLCALNN 
421:	TCEYGLHNSY SVMQLMSAWG PFIYGGCWAA TLSTALTNLL SVPRLIQALG VDRIYPGLIF 
481:	FSKPYGRHGE PYRGYVLTFF VSLLFLLIAD LNTIAPLISN FYLASYALIN FCTFHRALVR 
541:	PLGWRPTFRY YNMWLSLAGF LMCVAIMLLV HWVMSLVTFA IFFTLYLIVH YRRPDVNWGS 
601:	STQAQMYKTA LSSAHALART GEHVKNYWPQ LLVLAGRPQA RPALVDLGNL ISKAGSLMIV 
661:	GDISQEKLSY KVRSARARSD DEWLRGRKVR AFCSRVHGFS FEPGARALVQ GSGVGRLAPN 
721:	VLLMGYKSDW TTCPANDLVS YFNVLHTAFE NRLAVAIVRV SGGLDYSAVV SEGAEEGAAG 
781:	SLTATSSSGE LRVRRDGLIM HADSDLDIRD TQPKHNLSNL LTLTTSRSFT ISECKEKDKK 
841:	KKERKPNDMH RQIVYNTASG LELSKFQLAQ MSLFQKKQES GTLDVWWLYD DGGLTILLPY 
901:	IISQRSAWAN CKLRIFALAN RLHEMELEER NMANLLAKFR IDYSSLTMVQ DITDPPQPET 
961:	KALFDETIKK FTEESASPDC RISDMELQTL AVKTNRQLRL RELLLANSKD ARLVVMSLPM 
1021:	PRKGSISAPL YMAWLEMMSR DLPPMLFVRG NHTSVLTFYS