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2.A.35.1.1
Na+:H+ antiporter (Ito et al. 1997).

Accession Number:P27611
Protein Name:NhaC
Length:462
Molecular Weight:49541.00
Species:Bacillus firmus [398511]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Pfam: PF03553   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport

References (2)

[1] “Molecular cloning and sequencing of a gene from alkaliphilic Bacillus firmus OF4 that functionally complements an Escherichia coli strain carrying a deletion in the nhaA Na+/H+ antiporter gene.”  Ivey D.M.et.al.   1660475
[2] “Role of the nhaC-encoded Na+/H+ antiporter of alkaliphilic Bacillus firmus OF4.”  Ito M.et.al.   9190799

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEKKATVGFT LLLLGVMMAI IIASMFVLKV EPHIPLVVCL LIAAVFGRYL RVGWNDLESA 
61:	MIDGLKIGIK PIFILALVGI VIAVWMMSGT VPTLLFYGLS IISPEWFAVS TLLICMIVSS 
121:	FTGSSFTTVG TIGVAMMGIG TALGIDPAIA AGAVVCGACF GDKMSPLSDT TNFAPGIVGV 
181:	DLFDHIRHLL WTTVPSFVIT VILFLMIGRS QATSTTQDIQ AMLTALDSQF TLSVLTLLSP 
241:	LLVVILAMRR FPTIPVLVVG ILTGIITAAF VQGNADVVRW FTIIQNGFSM ETGNEVIDGI 
301:	VNRGGLQSMM WSISLVMIAL TLGGVIQRIG VIDTLLQSAN KKIIFTWTFD CSDSTSSIGV 
361:	NVVTGEQYLS ILLPGKTFES FYTKLNVAKK NLSRTLEDAG TLVNPLIPWG VSGAFFASTL 
421:	GVDVIDYLPF AFFLFLSPFM TILFGYLGIG VGKEQSLANK RG