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2.A.35.1.6
YheL; TyrT, putative tyrosine uptake cation symporter; NhaC, putative Na+/H+ antiporter (Sodium/hydrogen antiporter) (Rodionov et al. 2004).

Accession Number:O07553
Protein Name:Na(+)/H(+) antiporter NhaC
Length:453
Molecular Weight:48053.00
Species:Bacillus subtilis (strain 168) [224308]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: COG1757
HEGENOM: HOG000283662
Entrez Gene ID: 936274   
Pfam: PF03553   
KEGG: bsu:BSU09680   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0006814 P:sodium ion transport

References (5)

[1] “The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus subtilis chromosome contains several dysfunctional genes, the glyB marker, many genes encoding transporter proteins, and the ubiquitous hit gene.”  Noback M.A.et.al.   9579061
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Two types of Bacillus subtilis tetA(L) deletion strains reveal the physiological importance of TetA(L) in K(+) acquisition as well as in Na(+), alkali, and tetracycline resistance.”  Wang W.et.al.   10735849
[4] “Bacillus subtilis YqkI is a novel malic/Na+-lactate antiporter that enhances growth on malate at low protonmotive force.”  Wei Y.et.al.   10903309
[5] “Bacillus subtilis NhaC, an Na+/H+ antiporter, influences expression of the phoPR operon and production of alkaline phosphatases.”  Pragai Z.et.al.   11274110

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDSQKKLTFP LAVGLFIFML CIIISCLFLL HVEPHIPLFL SVVMLSAAAL WFGFPWKSIE 
61:	KGIVDGIKNG VQPIIVLALI GILIGAWMYS GAIPTMTVYA LSFIEPSHLL LTALFSCMII 
121:	STLVGSSLTT VSTIGVALIG VASAAGVPLE WTAGAVICGA CFGDKMSPMS DTTNFAAGIG 
181:	EIPIFEHIRH MMGTTIPALL ITVVLFYFLG SSVSADAAST DNIQQVITGI KDAANVTPWA 
241:	LLSPLLVVLL AMKRVSVIPV LTAGIISSGI LTAIFVPYSS LQAFMTALQN GTTFETDNEA 
301:	AAKIINRGGL QSMMGSVSLI MIAFALGGLM EKIGLISALL EGVMKGIRSK GRLVAATVCS 
361:	SIGVNLATGE QYLSILIPGQ SFKSLYDKRN IQRKFLTRSL EDGGTLINPL IPWGVSGAFM 
421:	ASALGVPVID YIPFTFFLYI SPMISILIGF VKK