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2.A.35.2.1
Na+/H+ antiporter of the NhaC family

Accession Number:Q6LZF0
Protein Name:NhaC homologue
Length:525
Molecular Weight:55424.00
Species:Methanococcus maripaludis [39152]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Secreted1
Substrate Na+, H+

Cross database links:

HEGENOM: HBG741626
RefSeq: NP_987799.1   
Entrez Gene ID: 2762215   
Pfam: PF03553   
BioCyc: MMAR267377:MMP0679-MONOMER   
KEGG: mmp:MMP0679   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport

References (1)

[1] “Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis.”  Hendrickson E.L.et.al.   15466049

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDFGILSLLP PVVAIGLALI TKRVYMSLFL GILAGSLLYN NWNIVASASH IVNTIIGSVE 
61:	LTSITGISSF TGVGNLWNLL ILLFLVMLGI LIALITRAGG ALAYGNWAST KIKSKEGASL 
121:	STSLLGILLF IDDYFNCLTV GTVMKPITDK FKISRAKLAY IIDSTAAPVC ILMPVSSWFA 
181:	AVVGNLGESG VGTGALSSMS PSGVFFSAIL YNTYALVALF MVSFIISFKK MDFGPMKVHE 
241:	KVATETGDLF NGDAETAAIE SEIEPLSGGK ISYLVLPLVV LILAIIFAFM ISGGLFAGVG 
301:	IIESFLSMDA SWGLFWGGLV TLLFTVIYFI VSKAVPAKDI ANLFAKGSKL MLPAITILIL 
361:	AWSLGSVIGD LGTGTYLSSL IQNSLPVQIL PAILFLLSGF MAFSTGTSWG TFGIMLPIAV 
421:	PMAVGLGMPE FVVPFVAAVL GGAIYGDHSS PISDTTIMSS TGAGTKHIDH VQTQLPYTTL 
481:	IGIMAFLGYL IVGYTINLGY WVSGLINLAF VAFAVYIGAS FLSKK