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2.A.35.2.3
The NhaC Na+:H+ antiporter, G1-NhaC (functions in Na+ extrusion at lower pH values and in pH homeostasis at pH 10 under Na+-limiting conditions) (Liew et al., 2007).

Accession Number:Q0PHV8
Protein Name:G1-NhaC
Length:535
Molecular Weight:57844.00
Species:Bacillus sp. G1 [159632]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Pfam: PF03553   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport

References (1)

[1] “Expression of the Na+/H+ antiporter gene (g1-nhaC) of alkaliphilic Bacillus sp. G1 in Escherichia coli.”  Liew C.W.et.al.   17937670

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEHIGWLSLS RQCGVNISDY NKEGIYILRD CHLIGCFYCI LWLDASNRGC FQTVISFFVS 
61:	FETLDQPSFA GFVESMTENG ISINDWELYI MLFLVFLGIV ASLITFSGGG QAFSHWAEKR 
121:	ITTRKGSLFL PFVLGLVIFI DDYFNALTVG NTSRPLTDRY RVSRAKLSYI VDSTSAPICV 
181:	IAPMSSWGAY IIGIFASIFA ANQIIEFSPL QAFIYTIPIN FYALIALIFI VLVIVFNIDV 
241:	GAMKQHEDRA KKENQLTDPA KGEVPGSLSE DLTMAHGRVS QLFIPILVLV VATVGMMLYT 
301:	GAQGASHDGV DVTVLTVMEY TDIGLSLLIG SAIGLVVTMG MTLMARPNKS DFGKAVMAGI 
361:	QSMLPAIGIL VLAWTTIEMI GLLGTGNYLA SLIDQSIHPG FLPVLLFLVA FAFSGLATGT 
421:	SWGTFGMLLP IAAQIAVVVE PTMLIPMLAA VLAGSIFGDH ISPISDTTIL SAAGSGAHHM 
481:	DHVITQLPYA ILTAVLATIA FFILGFLGAV IAWIVVGILL TITVFILQRV SKKET