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2.A.36.1.11
The Na+:H+ Exchanger, NHE1, is developmentally regulated and necessary for cell polarity (Patel and Barber, 2005).

Accession Number:Q552S0
Protein Name:Sodium/hydrogen exchanger 1
Length:674
Molecular Weight:75521.00
Species:Dictyostelium discoideum (Slime mold) [44689]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: KOG1965 KOG1965
HEGENOM: HBG445564 HBG445564
Entrez Gene ID: 8620198   
Pfam: PF00999   
KEGG: ddi:DDB_G027571   

Gene Ontology

GO:0005737 C:cytoplasm
GO:0016021 C:integral to membrane
GO:0031256 C:leading edge membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0051453 P:regulation of intracellular pH

References (4)

[1] “Sequence and analysis of chromosome 2 of Dictyostelium discoideum.”  Gloeckner G.et.al.   12097910
[2] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[3] “A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis.”  Patel H.et.al.   15851518
[4] “Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains.”  Carilla-Latorre S.et.al.   18590548

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKLNKSYILI VVLLLSLFYS SVSSTKTTLI KSNNHYNSDN SNNDNKNINI NNNNDGDGDD 
61:	DDDNNKILIT PENQNHLIHD IGIDSSSTEI LFGSSSNSGS CGEKNNTKQN ALANQREANT 
121:	IIFIIMLILT GSVLIVYFII SLDIPFVPES VAVVTYGIIL GIVFRFFYSD IVNHVVSFEP 
181:	ENFFLFILPT IIFETGYSLH KTDFFNNIGP ILMFAVFGTI ITFLVVGFGI YIVGYFGVSI 
241:	ALSLKDSFAF GSIISSTDPV CTLAIFQALN VDPMLYILVL GESILNDATS MMLYSVVEDT 
301:	STRDIIISCA MFTVVAIGSV ILGVVMALLL SLILKWINIG KFPALETIFM VMFSYMSYVL 
361:	AGALDISGVL AVFFFGITLN QYGAYSLSPY TKLTSGQLFR TAAFISETFL FLYFGLSLTA 
421:	HEFKFDLGLF SWSILFTCLA RAISVFPMCF LLNKFLKTKI PWVIQVAIWF AGLRGAFAFS 
481:	LSLDYISEDE HMNAYIRTNT LLVVVFTIFV FGMGTYPLLR VLGIKTSQTD QSLDNISKPM 
541:	SKQTKQKDRT KLYESFDDKY FKPWFRKRVP PLANEAIEIF EKMVIQSSHD HELDSNPLRF 
601:	DDDEEDDDDE DLDFDSDLDL NININTDSIH QSDNNNNDNG NNNNNNNNII INNNSQHHSN 
661:	DGSNNKNNDT LPLI