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2.A.36.1.15
Sodium/hydrogen exchanger 3 (Na+/H+ exchanger 3) (NHE-3) (Solute carrier family 9 member 3) (Dominguez Rieg et al. 2016).

Accession Number:P48764
Protein Name:Sodium/hydrogen exchanger 3
Length:834
Molecular Weight:92855.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Genevestigator: P48764
eggNOG: COG0025
HEGENOM: HOG000247044
Entrez Gene ID: 6550   
Pfam: PF00999   
KEGG: hsa:6550   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005903 C:brush border
GO:0031526 C:brush border membrane
GO:0009986 C:cell surface
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0007623 P:circadian rhythm
GO:0006898 P:receptor-mediated endocytosis
GO:0006885 P:regulation of pH
GO:0002028 P:regulation of sodium ion transport
GO:0051384 P:response to glucocorticoid stimulus

References (4)

[1] “Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3.”  Brant S.R.et.al.   7631746
[2] “The DNA sequence and comparative analysis of human chromosome 5.”  Schmutz J.et.al.   15372022
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism.”  Zachos N.C.et.al.   19088451

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MWGLGARGPD RGLLLALALG GLARAGGVEV EPGGAHGESG GFQVVTFEWA HVQDPYVIAL 
61:	WILVASLAKI GFHLSHKVTS VVPESALLIV LGLVLGGIVW AADHIASFTL TPTVFFFYLL 
121:	PPIVLDAGYF MPNRLFFGNL GTILLYAVVG TVWNAATTGL SLYGVFLSGL MGDLQIGLLD 
181:	FLLFGSLMAA VDPVAVLAVF EEVHVNEVLF IIVFGESLLN DAVTVVLYNV FESFVALGGD 
241:	NVTGVDCVKG IVSFFVVSLG GTLVGVVFAF LLSLVTRFTK HVRIIEPGFV FIISYLSYLT 
301:	SEMLSLSAIL AITFCGICCQ KYVKANISEQ SATTVRYTMK MLASSAETII FMFLGISAVN 
361:	PFIWTWNTAF VLLTLVFISV YRAIGVVLQT WLLNRYRMVQ LEPIDQVVLS YGGLRGAVAF 
421:	ALVVLLDGDK VKEKNLFVST TIIVVFFTVI FQGLTIKPLV QWLKVKRSEH REPRLNEKLH 
481:	GRAFDHILSA IEDISGQIGH NYLRDKWSHF DRKFLSRVLM RRSAQKSRDR ILNVFHELNL 
541:	KDAISYVAEG ERRGSLAFIR SPSTDNVVNV DFTPRSSTVE ASVSYLLREN VSAVCLDMQS 
601:	LEQRRRSIRD AEDMVTHHTL QQYLYKPRQE YKHLYSRHEL TPTEDEKQDR EIFHRTMRKR 
661:	LESFKSTKLG LNQNKKAAKL YKRERAQKRR NSSIPNGKLP MESPAQNFTI KEKDLELSDT 
721:	EEPPNYDEEM SGGIEFLASV TKDTASDSPA GIDNPVFSPD EALDRSLLAR LPPWLSPGET 
781:	VVPSQRARTQ IPYSPGTFCR LMPFRLSSKS VDSFLQADGP EERPPAALPE STHM