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2.A.36.1.16
Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5)

Accession Number:Q14940
Protein Name:Sodium/hydrogen exchanger 5
Length:896
Molecular Weight:99011.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Genevestigator: Q14940
eggNOG: COG0025
HEGENOM: HOG000247044
Entrez Gene ID: 6553   
Pfam: PF00999   
KEGG: hsa:6553   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006885 P:regulation of pH

References (4)

[1] “Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain.”  Baird N.R.et.al.   9933641
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1.”  Klanke C.A.et.al.   7759094
[4] “beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.”  Szabo E.Z.et.al.   15699339

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MLRAALSLLA LPLAGAAEEP TQKPESPGEP PPGLELFRWQ WHEVEAPYLV ALWILVASLA 
61:	KIVFHLSRKV TSLVPESCLL ILLGLVLGGI VLAVAKKAEY QLEPGTFFLF LLPPIVLDSG 
121:	YFMPSRLFFD NLGAILTYAV VGTLWNAFTT GAALWGLQQA GLVAPRVQAG LLDFLLFGSL 
181:	ISAVDPVAVL AVFEEVHVNE TLFIIVFGES LLNDAVTVVL YKVCNSFVEM GSANVQATDY 
241:	LKGVASLFVV SLGGAAVGLV FAFLLALTTR FTKRVRIIEP LLVFLLAYAA YLTAEMASLS 
301:	AILAVTMCGL GCKKYVEANI SHKSRTTVKY TMKTLASCAE TVIFMLLGIS AVDSSKWAWD 
361:	SGLVLGTLIF ILFFRALGVV LQTWVLNQFR LVPLDKIDQV VMSYGGLRGA VAFALVILLD 
421:	RTKVPAKDYF VATTIVVVFF TVIVQGLTIK PLVKWLKVKR SEHHKPTLNQ ELHEHTFDHI 
481:	LAAVEDVVGH HGYHYWRDRW EQFDKKYLSQ LLMRRSAYRI RDQIWDVYYR LNIRDAISFV 
541:	DQGGHVLSST GLTLPSMPSR NSVAETSVTN LLRESGSGAC LDLQVIDTVR SGRDREDAVM 
601:	HHLLCGGLYK PRRRYKASCS RHFISEDAQE RQDKEVFQQN MKRRLESFKS TKHNICFTKS 
661:	KPRPRKTGRR KKDGVANAEA TNGKHRGLGF QDTAAVILTV ESEEEEEESD SSETEKEDDE 
721:	GIIFVARATS EVLQEGKVSG SLEVCPSPRI IPPSPTCAEK ELPWKSGQGD LAVYVSSETT 
781:	KIVPVDMQTG WNQSISSLES LASPPCNQAP ILTCLPPHPR GTEEPQVPLH LPSDPRSSFA 
841:	FPPSLAKAGR SRSESSADLP QQQELQPLMG HKDHTHLSPG TATSHWCIQF NRGSRL