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2.A.36.1.18
Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4)

Accession Number:Q6AI14
Protein Name:Sodium/hydrogen exchanger 4
Length:798
Molecular Weight:89814.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Genevestigator: Q6AI14
eggNOG: COG0025
HEGENOM: HOG000247044
Entrez Gene ID: 389015   
Pfam: PF00999   
KEGG: hsa:389015   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006811 P:ion transport
GO:0006885 P:regulation of pH
GO:0055085 P:transmembrane transport

References (3)

[1] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[2] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[3] “Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.”  Denis N.J.et.al.   17370265

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MALQMFVTYS PWNCLLLLVA LECSEASSDL NESANSTAQY ASNAWFAAAS SEPEEGISVF 
61:	ELDYDYVQIP YEVTLWILLA SLAKIGFHLY HRLPGLMPES CLLILVGALV GGIIFGTDHK 
121:	SPPVMDSSIY FLYLLPPIVL EGGYFMPTRP FFENIGSILW WAVLGALINA LGIGLSLYLI 
181:	CQVKAFGLGD VNLLQNLLFG SLISAVDPVA VLAVFEEARV NEQLYMMIFG EALLNDGITV 
241:	VLYNMLIAFT KMHKFEDIET VDILAGCARF IVVGLGGVLF GIVFGFISAF ITRFTQNISA 
301:	IEPLIVFMFS YLSYLAAETL YLSGILAITA CAVTMKKYVE ENVSQTSYTT IKYFMKMLSS 
361:	VSETLIFIFM GVSTVGKNHE WNWAFICFTL AFCQIWRAIS VFALFYISNQ FRTFPFSIKD 
421:	QCIIFYSGVR GAGSFSLAFL LPLSLFPRKK MFVTATLVVI YFTVFIQGIT VGPLVRYLDV 
481:	KKTNKKESIN EELHIRLMDH LKAGIEDVCG HWSHYQVRDK FKKFDHRYLR KILIRKNLPK 
541:	SSIVSLYKKL EMKQAIEMVE TGILSSTAFS IPHQAQRIQG IKRLSPEDVE SIRDILTSNM 
601:	YQVRQRTLSY NKYNLKPQTS EKQAKEILIR RQNTLRESMR KGHSLPWGKP AGTKNIRYLS 
661:	YPYGNPQSAG RDTRAAGFSD DDSSDPGSPS ITFSACSRIG SLQKQEAQEI IPMKSLHRGR 
721:	KAFSFGYQRN TSQEEYLGGV RRVALRPKPL FHAVDEEGES GGESEGKASL VEVRSRWTAD 
781:	HGHGRDHHRS HSPLLQKK