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2.A.36.1.21
Sodium:proton antiporter of 468 aas and 13 TMSs, Sod2 or NHE1.  Residues within TMS 11 play important roles in transport, suggesting that this TMS forms part of the ion translocation core (Dutta et al. 2017).

Accession Number:P36606
Protein Name:NAH aka Nha1 aka SOD2 aka SPAC977.10
Length:468
Molecular Weight:52177.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

eggNOG: fuNOG05622
RefSeq: NP_592782.1   
Entrez Gene ID: 2543239   
Pfam: PF00999   
KEGG: spo:SPAC977.10   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0042175 C:nuclear membrane-endoplasmic reticulum network
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006883 P:cellular sodium ion homeostasis
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.”  Jia Z.-P.et.al.   1314171
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[3] “Identification and localization of the sod2 gene product in fission yeast.”  Dibrov P.et.al.   9094438
[4] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517
Structure:
2M7X     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGWRQLDIDK VHLALIVAGG FITFFCYFSE VFRKKLLVGE AVLGSITGLI FGPHAAKLVD 
61:	PFSWGDHGDY LTVEICRIVL DVRVFASAIE LPGAYFQHNF RSIIVMLLPV MAYGWLVTAG 
121:	FAYALFPQIN FLGSLLIAGC ITSTDPVLSA LIVGEGPLAK KTPERIRSLL IAESGCNDGM 
181:	AVPFFYFAIK LLTVKPSRNA GRDWVLLVVL YECAFGIFFG CVIGYLLSFI LKHAQKYRLI 
241:	DAISYYSLPL AIPLLCSGIG TIIGVDDLLM SFFAGILFNW NDLFSKNISA CSVPAFIDQT 
301:	FSLLFFTYYG TIIPWNNFNW SVEGLPVWRL IVFSILTLVC RRLPVVFSVK PLVPDIKTWK 
361:	EALFVGHFGP IGVCAVYMAF LAKLLLSPDE IEKSIYESTT VFSTLNEIIW PIISFVILSS 
421:	IIVHGFSIHV LVIWGKLKSL YLNRKVTKSD SDLELQVIGV DKSQEDYV