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2.A.36.1.3
Na+/K+:H+ antiporter, Nhe-7, present in the Golgi apparatus and endosomes. There are four isoforms, NHE6-9. They regulate the luminal pH as well as intracellular trafficking, and function in cell polarity development (Ohgaki et al., 2011). Nhe-6 (Nhe6) is associated with X-linked intellectural disability and autism when processing and trafficking is impaired (Ilie et al. 2013).

Accession Number:Q96T83
Protein Name:Nhe-7
Length:725
Molecular Weight:80131.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Golgi apparatus1 / Multi-pass membrane protein2
Substrate Na+, K+, H+

Cross database links:

Genevestigator: Q96T83 Q96T83
eggNOG: prNOG04301 COG0025
HEGENOM: HBG443570 HOG000172307
RefSeq: NP_115980.1   
Entrez Gene ID: 84679   
Pfam: PF00999   
OMIM: 300368  gene
KEGG: hsa:84679    hsa:84679   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0055038 C:recycling endosome membrane
GO:0005802 C:trans-Golgi network
GO:0015386 F:potassium:hydrogen antiporter activity
GO:0042803 F:protein homodimerization activity
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006813 P:potassium ion transport
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0000139 C:Golgi membrane

References (8)

[1] “Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.”  Numata M.et.al.   11279194
[2] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[3] “Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7.”  Lin P.J.et.al.   15840657
[4] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332
[5] “Molecular cloning and characterization of a novel (Na+,K+)/H+ exchanger localized to the trans-Golgi network.”  Numata M.et.al.   11279194
[6] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[7] “Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7.”  Lin P.J.et.al.   15840657
[8] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.”  Mayya V.et.al.   19690332

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEPGDAARPG SGRATGAPPP RLLLLPLLLG WGLRVAAAAS ASSSGAAAED SSAMEELATE 
61:	KEAEESHRQD SVSLLTFILL LTLTILTIWL FKHRRVRFLH ETGLAMIYGL IVGVILRYGT 
121:	PATSGRDKSL SCTQEDRAFS TLLVNVSGKF FEYTLKGEIS PGKINSVEQN DMLRKVTFDP 
181:	EVFFNILLPP IIFHAGYSLK KRHFFRNLGS ILAYAFLGTA VSCFIIGNLM YGVVKLMKIM 
241:	GQLSDKFYYT DCLFFGAIIS ATDPVTVLAI FNELHADVDL YALLFGESVL NDAVAIVLSS 
301:	SIVAYQPAGL NTHAFDAAAF FKSVGIFLGI FSGSFTMGAV TGVNANVTKF TKLHCFPLLE 
361:	TALFFLMSWS TFLLAEACGF TGVVAVLFCG ITQAHYTYNN LSVESRSRTK QLFEVLHFLA 
421:	ENFIFSYMGL ALFTFQKHVF SPIFIIGAFV AIFLGRAAHI YPLSFFLNLG RRHKIGWNFQ 
481:	HMMMFSGLRG AMAFALAIRD TASYARQMMF TTTLLIVFFT VWIIGGGTTP MLSWLNIRVG 
541:	VEEPSEEDQN EHHWQYFRVG VDPDQDPPPN NDSFQVLQGD GPDSARGNRT KQESAWIFRL 
601:	WYSFDHNYLK PILTHSGPPL TTTLPAWCGL LARCLTSPQV YDNQEPLREE DSDFILTEGD 
661:	LTLTYGDSTV TANGSSSSHT ASTSLEGSRR TKSSSEEVLE RDLGMGDQKV SSRGTRLVFP 
721:	LEDNA