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2.A.36.1.4
Cl--dependent Na+:H+ antiporter (Nhe) (residues 1-375 are identical to Nhe-1 [TC #2.A.36.1.1]).

Accession Number:Q8R4H8
Protein Name:NHE aka Chloride-dependent sodium/hydrogen exchanger
Length:438
Molecular Weight:48482.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Genevestigator: Q8R4H8
Pfam: PF00999   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0016021 C:integral to membrane
GO:0045121 C:membrane raft
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0008134 F:transcription factor binding
GO:0030154 P:cell differentiation
GO:0016049 P:cell growth
GO:0045768 P:positive regulation of anti-apoptosis
GO:0007243 P:intracellular protein kinase cascade
GO:0006885 P:regulation of pH
GO:0042493 P:response to drug
GO:0014070 P:response to organic cyclic substance
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Cloning and expression of a chloride-dependent Na+-H+ exchanger.”  Sangan P.et.al.   11773056

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMLRWSGIWG LYPPRIFPSL LVVVALVGLL PVLRSHGLQL NPTASTIRGS EPPRERSIGD 
61:	VTTAPSEPVH HPDDRNLTNL YIEHGAKPVR KAFPVLDIDY LHVRTPFEIS LWILLACLMK 
121:	IGFHVIPTIS SIVPESCLLI VVGLLVGGLI KGVGETPPFL QSDVFFLFLL PPIILDAGYF 
181:	LPLRQFTENL GTILIFAVVG TLWNAFFLGG LLYAVCLVGG EQINNIGLLD TLLFGSIISA 
241:	VDPVAVLAVF EEIHINELLH ILVFGESLLN DAVTVVLYHL FEEFASYEYV GISDIFLGFL 
301:	SFFVVSLGGV FVGVVYGVIA AFTSRFTSHI RVIEPLFVFL YSYMAYLSAE LFHLSGIMAL 
361:	IASGVVMRPY VEANISRPLH AVPVLAGIVP QMIVQKNRID LNRRAFTPFF KQLHKTVPDQ 
421:	LDTPNRATSN FHFLFISI