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2.A.36.1.7
The basolateral intestinal Na+/H+ antiporter PBO-4 (Beg et al., 2008)

Accession Number:Q21386
Protein Name:PBO-4
Length:783
Molecular Weight:88410.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: meNOG05927
HEGENOM: HBG387498
RefSeq: NP_509830.2   
Entrez Gene ID: 181285   
Pfam: PF00999   
KEGG: cel:K09C8.1   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.”  Nehrke K.et.al.   12021279

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MWIKLLFFFT TLLVSTSGLG DDGITALLDP NSTEFSTVLP SNNSEKFSYM LASVKNMNMT 
61:	ASEFEEFIKV LKHRQSKDHS GEHVGNEHDE SHGISVVSWH WDYVKNELVL TLFFIVIGLF 
121:	KLVYHHTFVT RKILPESCCL IFIGIAIGFF FVGDATHASI KFLEFKSKVF FFYLLPPIIL 
181:	ESAYSLKDRA FIENIGTILL YAVVGTILNI VLLAAALLIL IWVGIMGKYN LSVMDILTFA 
241:	SLVAAVDPVA VLAVFQEVGV NKMLYFMVFG ESLFNDAVTI VCYNLAIEFQ TLPDFTWYHG 
301:	FLGLLSFLCV SIGGLIIGLI CGAISSFVTK FTTDVRVVEP VVLFGMAYLA YLGSEMFHFS 
361:	GIIALIACGL FQTHYACCNI SYKSFTSVMY ITKVCSTLCE SLIFIILGVM LVNEREWFWT 
421:	DWHPVFSAVS VVLCVVVRFG VTFFLTYFVN QFTGGVRHIS FQEQFIMSYG GLRGAVSFSL 
481:	VFMISANPDV KNTMLGATYA VILFTNIIQG STIKLFVKWL NIRLAKKEDH FRLFIEFNNG 
541:	MVQHLSQGIE DLCGDKSLSL INRMSELSKK YVRPLLEKNY TANKAKKEGK LVELNRAVAM 
601:	REALNNSPSQ SSFQRQHTID EMAESGALPH DLLDEEHQGH HHHGQVHPDN EDADQRANEL 
661:	IKDVSSIRQL MHNPFEDCYL DRNLTHEEEK EQARLKMKKT RAFKFSSVRK TIGFFGKKKS 
721:	VRRHATQQGI LHSAIATIGV QSVDRPSTST RVSVEDEEQG LTMKEMEEEH PLMTITESEE 
781:	TSF