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2.A.36.1.8
Na+/H+ exchanger, Nhx-2 (Pfeiffer et al., 2008)

Accession Number:Q09432
Protein Name:Nhx-2
Length:627
Molecular Weight:70650.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cytoplasm1 / Single-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: meNOG05927
RefSeq: NP_495614.3   
Entrez Gene ID: 174242   
Pfam: PF00999   
KEGG: cel:B0495.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0010171 P:body morphogenesis
GO:0008340 P:determination of adult lifespan
GO:0040007 P:growth
GO:0019915 P:lipid storage
GO:0002119 P:nematode larval development
GO:0040010 P:positive regulation of growth rate
GO:0006885 P:regulation of pH
GO:0000003 P:reproduction
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSYVGAECEE EEKEYPSRYP IAYFEWENVK IPMTICLWLI GASIAKIIFN LIPHLNELFP 
61:	DSALLIMIGL IIGIIFKLIG VNKNAFFLES EVFMLYLLPP LVFDAGYFMP ARQFFDNFGS 
121:	ILCFAMIGTS FNIVAIALSL WAISLTGLFS VETPLMHMLL FGSVAADVDP VAVIVIFEEL 
181:	KVNEVLFIAV FGESLLNDGV AVVLYRMFLT FSEIGTENLI TSDYINGGVS FLVVAFGGIG 
241:	IGLLFAFLTS LVTRFARDEE VKVLNSVFIL ILPYTCYLCG ELFGLSSIMA IVFCGAAMRQ 
301:	YCRENVDPDT VKATESFIKV LSLASETVIF VFLGLSTVSS NHHWDTSFIV LTVVFCLIYR 
361:	TLGVVVMCYF LNKYRLNKYT KVDQFIMAYG GLRGAIAYGL VVAIPDFIPG KNMFVTSCII 
421:	VIYFTVFLQG ITLKPIAEFL QVEKKNVHSK NMIEHIYSEL IDTTMAGMED IAGFKGHHWI 
481:	RDSWNALNNN YLRPILVNKN NMKEMDKTKL VRKYKHLVDE DAKKIARGDL NSNMVFTKAL 
541:	IEHTRSRTNT MIDGVSSTSK IDFTKHMKEN FGVTVYDDHS TVPMTPTHLF QETTEVEYSV 
601:	RSEINDNDGF ENDGYESDES GSFHERV