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2.A.36.1.9
Human Na+/H+ Exchanger, NHE-8 or SLC9A8. Functions in intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia. It attenuates Ca2+ influx in the proximal tubular epithelium (Wiebe et al. 2019).

Accession Number:Q9Y2E8
Protein Name:Sodium/hydrogen exchanger 8
Length:581
Molecular Weight:65422.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

COG0025
Genevestigator: Q9Y2E8 Q9Y2E8
HEGENOM: HBG445564 HOG000172307
RefSeq: NP_056081.1   
Entrez Gene ID: 23315   
Pfam: PF00999   
KEGG: hsa:23315    hsa:23315   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0015386 F:potassium:hydrogen antiporter activity
GO:0006811 P:ion transport
GO:0051453 P:regulation of intracellular pH

References (16)

[1] “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Nagase T.et.al.   10231032
[2] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.”  Nakajima D.et.al.   12168954
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[5] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi Compartments and are involved in organelle pH regulation.”  Nakamura N.et.al.   15522866
[8] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[9] “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Nagase T.et.al.   10231032
[10] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.”  Nakajima D.et.al.   12168954
[11] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[12] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[13] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[15] “Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi Compartments and are involved in organelle pH regulation.”  Nakamura N.et.al.   15522866
[16] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ AQQEEQSSGM 
61:	TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM GAVIKIIEFK KLANWKEEEM 
121:	FRPNMFFLLL LPPIIFESGY SLHKGNFFQN IGSITLFAVF GTAISAFVVG GGIYFLGQAD 
181:	VISKLNMTDS FAFGSLISAV DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA 
241:	EGLTRKNMSD VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG 
301:	MMIIFAYLPY GLAEGISLSG IMAILFSGIV MSHYTHHNLS PVTQILMQQT LRTVAFLCET 
361:	CVFAFLGLSI FSFPHKFEIS FVIWCIVLVL FGRAVNIFPL SYLLNFFRDH KITPKMMFIM 
421:	WFSGLRGAIP YALSLHLDLE PMEKRQLIGT TTIVIVLFTI LLLGGSTMPL IRLMDIEDAK 
481:	AHRRNKKDVN LSKTEKMGNT VESEHLSELT EEEYEAHYIR RQDLKGFVWL DAKYLNPFFT 
541:	RRLTQEDLHH GRIQMKTLTN KWYEEVRQGP SGSEDDEQEL L