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2.A.36.3.3
Uncharacterized Na(+)/H(+) exchanger Rv2287/MT2345

Accession Number:P65526
Protein Name:Uncharacterized Na(+)/H(+) exchanger Rv2287/MT2345
Length:542
Molecular Weight:57491.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: COG0025
HEGENOM: HOG000263348
Entrez Gene ID: 887570    924078   
Pfam: PF00999   
KEGG: mtc:MT2345    mtu:Rv2287   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015299 F:solute:hydrogen antiporter activity
GO:0006814 P:sodium ion transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNGRRTIGED GLVFGLVVIV ALVAAVVVGT VLGHRYRVGP PVLLILSGSL LGLIPRFGDV 
61:	QIDGEVVLLL FLPAILYWES MNTSFREIRW NLRVIVMFSI GLVIATAVAV SWTARALGME 
121:	SHAAAVLGAV LSPTDAAAVA GLAKRLPRRA LTVLRGESLI NDGTALVLFA VTVAVAEGAA 
181:	GIGPAALVGR FVVSYLGGIM AGLLVGGLVT LLRRRIDAPL EEGALSLLTP FAAFLLAQSL 
241:	KCSGVVAVLV SALVLTYVGP TVIRARSRLQ AHAFWDIATF LINGSLWVFV GVQIPGAIDH 
301:	IAGEDGGLPR ATVLALAVTG VVIATRIAWV QATTVLGHTV DRVLKKPTRH VGFRQRCVTS 
361:	WAGFRGAVSL AAALAVPMTT NSGAPFPDRN LIIFVVSVVI LVTVLVQGTS LPTVVRWARM 
421:	PEDVAHANEL QLARTRSAQA ALDALPTVAD ELGVAPDLVK HLEKEYEERA VLVMADGADS 
481:	ATSDLAERND LVRRVRLGVL QHQRQAVTTL RNQNLIDDIV LRELQAAMDL EEVQLLDPAD 
541:	AE