TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.36.4.2
Na+:H+ antiporter, Nha2 or Sod2-22.  Exports Na+ and Li+ but not K+.  Three residues, T141 in TMS 4, A179 in TMS 5 and V375 in TMS 11, determine the cation selectivity (Kinclova-Zimmermannova et al. 2015).

Accession Number:O42701
Protein Name:NAH2 aka Nha2 aka SOD22
Length:808
Molecular Weight:90198.00
Species:Zygosaccharomyces rouxii (Candida mogii) [4956]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, H+, Li+

Cross database links:

Pfam: PF00999    PF08619   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Characterization of a second gene (ZSOD22) of Na+/H+ antiporter from salt-tolerant yeast Zygosaccharomyces rouxii and functional expression of ZSOD2 and ZSOD22 in Saccharomyces cerevisiae.”  Iwaki T.et.al.   9791888

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAWSQLEVTK AHVAYSCVGI FSSIFSLVSL FVKEQLYIGE SMVASIFGLI VGPHCLNWFN 
61:	PLSWGNTDSI TLEISRILLC LQVFAVSVEL PRKYMLKHWV SVTMLLVPVM TSGWLVIALF 
121:	VWILVPGLNF PASLLMGACI TATDPVLAQS VVSGTFAQKV PGHLRNLLSC ESGCNDGLAI 
181:	PFVFLSLDLL LYPGRGGQIV KDWICVTILW ECIFGSILGC IIGYCGRKAI RFAEGRHIID 
241:	RESFLAFYLI LALTCAGFGS MLGVDDLLVS FFAGTAFAWD GWFAAKTHES NVSNVIDVLL 
301:	NYAYFVYLGS ILPWKDFNNP DIGLDVWRLI LLSLVVIFLR RIPAVLSLKP LIPDIKSWRE 
361:	AMFIGHFGPI GVGAVFAAIT SKSQLESHLT NEETPLKDTP GRGSKHWQVM ACIWPITCFS 
421:	IMTSVIVHGS SVAVIMLGRY LSTVTLMALP TGRTTNTKNA WLERLPALDK SGRPFSLQRL 
481:	DKEPSLSPGQ IGGRTSGMVA TPKLGMRQRW RQKLQDNKEI EPDIEMNNFC QGTFQIRKET 
541:	HASTNDSHGT TTANLGTSNG RAQGLPWRSK MNIIDRAEAV NTIYGLDKLA EDTENKDVWR 
601:	VNTSRIPGIR SPYDDVYTYQ SDSSSIGSIE RQRIKSLREQ EQQAYIAYTE DDQVIIENRQ 
661:	GEILEYVKFH KEGLGDAESG LHNHDRPKRA ISPPLEKLHQ ITNEARKNKY YAYKVGNDLV 
721:	IEDESGEVFR RYRISPHGGK RKIKKIINPV SSVLSSVGIT KPRGVSERIN HYLLHSEDEM 
781:	ADDEAESEND MDYEDSDGPA SRFKDHAD