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2.A.36.4.3
Na+:H+ antiporter, Nha1 or Sod1.  It provides salt tolerance by removing sodium or lithium ions in exchange for protons, and TMS 4 plays an important role (Ullah et al. 2013).

Accession Number:P36606
Protein Name:NAH aka Nha1 aka SOD2 aka SPAC977.10
Length:468
Molecular Weight:52177.00
Species:Schizosaccharomyces pombe (Fission yeast) [4896]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

eggNOG: fuNOG05622
RefSeq: NP_592782.1   
Entrez Gene ID: 2543239   
Pfam: PF00999   
KEGG: spo:SPAC977.10   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0042175 C:nuclear membrane-endoplasmic reticulum network
GO:0005886 C:plasma membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006883 P:cellular sodium ion homeostasis
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast.”  Jia Z.-P.et.al.   1314171
[2] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[3] “Identification and localization of the sod2 gene product in fission yeast.”  Dibrov P.et.al.   9094438
[4] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517
Structure:
2M7X     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGWRQLDIDK VHLALIVAGG FITFFCYFSE VFRKKLLVGE AVLGSITGLI FGPHAAKLVD 
61:	PFSWGDHGDY LTVEICRIVL DVRVFASAIE LPGAYFQHNF RSIIVMLLPV MAYGWLVTAG 
121:	FAYALFPQIN FLGSLLIAGC ITSTDPVLSA LIVGEGPLAK KTPERIRSLL IAESGCNDGM 
181:	AVPFFYFAIK LLTVKPSRNA GRDWVLLVVL YECAFGIFFG CVIGYLLSFI LKHAQKYRLI 
241:	DAISYYSLPL AIPLLCSGIG TIIGVDDLLM SFFAGILFNW NDLFSKNISA CSVPAFIDQT 
301:	FSLLFFTYYG TIIPWNNFNW SVEGLPVWRL IVFSILTLVC RRLPVVFSVK PLVPDIKTWK 
361:	EALFVGHFGP IGVCAVYMAF LAKLLLSPDE IEKSIYESTT VFSTLNEIIW PIISFVILSS 
421:	IIVHGFSIHV LVIWGKLKSL YLNRKVTKSD SDLELQVIGV DKSQEDYV