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2.A.36.4.4
The K+, Rb+ and other alkali metal cation efflux porter, Cnh1 (Kinclova-Zimmermannova and Sychrova, 2007). Transports Na+, K+, Li+ and Rb+ in several Candida species.  Confers tolerance to high salt concentrations (Krauke and Sychrova 2008).

Accession Number:Q9P937
Protein Name:CNH1
Length:796
Molecular Weight:88869.00
Species:Candida albicans (Yeast) [5476]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+, Na+, Rb+, Li+

Cross database links:

Pfam: PF00999    PF08619   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The Candida albicans antiporter gene CNH1 has a role in Na+ and H+ transport, salt tolerance, and morphogenesis.”  Soong T.W.et.al.   10832630

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAWSQLELEP PHIAYACVGI FSTLFSLVSL FVKERLYIGE ATVASIAGLI LGPHCLNWFD 
61:	PVSWGNSDYI TLEICRIVLC IQIVAVAVEL PKKYMMKHWL SVTIFLLPVM TCGWLIVGLF 
121:	IWCLIPHFTF NDGLLVSACV TATDPVLAAA VVGKGKFAER VPGHLRNLLS AESGCNDGMA 
181:	FPFIFLSLNL IIHSGHAGEI VKDWFLLTIL WECIFGCLLG TVIGYVLRKL VAFAENQNLI 
241:	DRESFLAIFV FIAFISAGIG SMLGVDDLLV SFAAGTAFGW NGAFAKKTEE SHVSTVIDLL 
301:	LNLSFFVYFG AIIPWPQFNN ADLGLNVWRL VVLAFVIIFL RRIPAVVALK PITPDVKTWR 
361:	EALFCGHFGP IGVGAIFASI LARKDLEAHY TTEETPLHHL PNEDFPHYQL LATIWPIVCF 
421:	IVITSIIVHG SSVAVLTLGK RLNRMAITMS FTTDQEGNGS GGWMQRLQKL DRTTTSFSLH 
481:	RVDTMAPTEK SQPETTGIKV RPAGGAKRKK NHKDDRTPPE AQILQLGGNK TPEPESASDT 
541:	LAIPNKTSRV ICIWRETTLQ KPKRHQCQPV AYQDGDQVII EDQYGEVMEN LKLTTKPVRA 
601:	PDIGSIHSME SLERHLTQYS TGSGEYTTDE DTHGLQEKLS RSLSRRSYYK KDDPNKRKVY 
661:	AHRVDDLIVI ENEDGDIIRR YKVNKHAPAP RARSGSIMGM VKSMVGIKPP PEISVTDLEH 
721:	GTQHKIILPE EENTPMSSKT EQKLEDTIAN ILQENHTQPI SEESADEEET EVEKKRRLQA 
781:	LGYLPSSRRD REDEEE