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2.A.36.6.1
Putative Na+:H+ antiporter, Nhe2

Accession Number:O29412
Protein Name:AF0846 aka Nhe2
Length:494
Molecular Weight:53710.00
Species:Archaeoglobus fulgidus [2234]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

RefSeq: NP_069680.1   
Entrez Gene ID: 1484065   
Pfam: PF00999   
BioCyc: AFUL224325:AF_0846-MONOMER   
KEGG: afu:AF0846   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015385 F:sodium:hydrogen antiporter activity
GO:0006885 P:regulation of pH
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.”  Klenk H.-P.et.al.   9389475

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIEENLVEFI EILMLATAVA VTVKFIRLPY TIALVLAGLF VGLAGLLPEV PLSREIVFFI 
61:	FLPPLLFEAA MNMDLKELRE NFGPIALIAF LGVVVTTTVV GFSLNWILGI PLALALIFGA 
121:	MVSATDPVSV LATFKSISAP KKLSILIEGE SVLNDGAAIV VFAIALEMML KGVFDPLNAA 
181:	LDFAVVCVGG AAVGLAVGYL AYRILAKIDD ALVEIAVTIV AAYLGFVLAE RFHFSGVIAV 
241:	VAAGLILGNY GRDFSMSPTT RVIMLDFWSV IVFLVNSIIF ILIGVNTHIT IFSAWKEILV 
301:	AIAAVILARA FVVYPVMTYY RFPNLWKHVV FWGGLRGVIP VALALSFGNQ LLSAMAFGVV 
361:	LFSLLLQGIS LEIFVKRKFV SESERELEEI IARYIAARSA KFELMKAVEQ GRIVEPVARE 
421:	MLPNLDAEIE ELRSKLEEKI RGGMGSKLRK AAVKYVIDAK KSAVVDAMAG GLVSQEVALE 
481:	IMRELDSKTA ELME