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2.A.36.6.3
K+:H+ antiporter, KhaP2 (NhaP2). Participates in volume control under low osmorality conditions (Radchenko et al., 2006; Resch et al., 2010)

Accession Number:Q87KV8
Protein Name:CvrA aka KhaP2
Length:581
Molecular Weight:62639.00
Species:Vibrio parahaemolyticus [670]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

HEGENOM: HBG359889
RefSeq: NP_799246.1   
Entrez Gene ID: 1190430   
Pfam: PF03471    PF00999    PF02080   
BioCyc: VPAR223926:VP2867-MONOMER   
KEGG: vpa:VP2867   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0003824 F:catalytic activity
GO:0015299 F:solute:hydrogen antiporter activity
GO:0006884 P:cell volume homeostasis
GO:0008152 P:metabolic process
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae.”  Makino K.et.al.   12620739

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDADTINSFF LIGALLIALS VLLSPVSSKL GIPILLVFLA VGMLAGEDGL GGILFDNYSI 
61:	AYLVSNLALA IILLDGGMRT RVASFRVALW PSVSLATIGV AITTLLTGLM ATWLFDLDLL 
121:	QGILVGAIVG STDAAAVFSL LKGRSLNERV GSTLEIESGT NDPMAVFLTV TLIAILSSTG 
181:	TGLSAGFLAL SFVKQFGIGA LLGFAGGWVL WKVINRNQLP DGLYSILTVS GGLIIFALSN 
241:	SLGGSGILSI YLVGLLLGNR PTRSRHSILH VLDGMTWLAQ IGMFLVLGLL VTPSNLLSIA 
301:	VPGLALAFGM ILFARPISVW IGLLPFKSFT PREKWFVSWV GLRGAVPIIL AVFPMMAGLP 
361:	DAQLYFNLAF FVVMVSLIVQ GGTLTKAMSL AKVELPPKPE PISRTGVEIY PTSEWELFIY 
421:	RLKADKWCIG EPLRSLSMPE GTRIAAVFRN QELLHPSGST RLEEDDTLCV LAQEKDLAAL 
481:	SLLFSEAPEK ASLTRFFGDF FLDIEVKLAD VAMMYGLNLG YELQDKTLSN IVEEQLGSTP 
541:	VLGDQFEWQG LQWVIADVVD HQVTKVGLRL PNEEEEGEEE D