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2.A.36.6.4
The K+(NH4+):H+ antiporter, NhaP (confers alkali resistance for alkaline pH homeostasis) (Wei et al., 2007)

Accession Number:Q0ZAH6
Protein Name:NhaP
Length:574
Molecular Weight:62268.00
Species:Alkalimonas amylolytica [152573]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+, Ammonium, H+

Cross database links:

Pfam: PF03471    PF00999   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015299 F:solute:hydrogen antiporter activity
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Three putative cation/proton antiporters from the soda lake alkaliphile Alkalimonas amylolytica N10 complement an alkali-sensitive Escherichia coli mutant.”  Wei Y.et.al.   17600061

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MEAINLTILV IGVLFLISIV ATLISSRIGA PILLVFLIIG MLAGEQGLGG ITFNNPQVAF 
61:	LIGSIALVII LFDGGMRTHP ERFRVALAPA AMLATLGVVV TCTVTGLAAA WILGLHWLQG 
121:	LLLGAILSST DAAAVFSIFQ SRGIRIKDRV ASTLEIESGS NDPMAVMLTI TLVGVLAEYT 
181:	ALDWSVLIVF LKQAIIGGAV GYGAGRLFVF LCRKLPLSFA FFPLMAVACC ISVYAVTTQF 
241:	EGSGFLAVYL MGYFVGNARL PQVLYILRVH DGLAWLSQIV MFLMLGLLVV PSQLLDHLLP 
301:	ALAIAGVLIF IARPLAVLLS LIPFHFPAKD QLFISWVGLR GAVPIILALF PWLAGVPDEH 
361:	LYFNVAFVIV IVSLVFQGWS ISPVARWLKL EVPKESGPDQ TMPLDAIASN EVIEVVSFTL 
421:	KGDSPMLDKQ WQDFTVPHSA EFLGVIRDGE WLLSRDNPVF KLKDSVLVLC KMADVPDIST 
481:	VLASAASSRT MTASDFFGDF VLNAQITLDE LDAFYSITLP EHESHVTLAD YITERFHRRV 
541:	VVGDQVKLDA LVLTVRQLDD HGNVKLVGIK PSDS