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2.A.36.6.5
K+:H+ antiporter NhaP2 (catalyzes K+:H+ and Na+:H+ exchange; Resch et al., 2010). (84% identical to 2.A.36.6.3). A cation binding pocket in the middle of the membrane and a pathway leading to it have been identified (Mourin et al. 2018).

Accession Number:Q9KNM9
Protein Name:Cell volume regulation protein A homolog
Length:581
Molecular Weight:62698.00
Species:Vibrio cholerae [666]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

HEGENOM: HBG359889
RefSeq: NP_232330.1   
Entrez Gene ID: 2615531   
Pfam: PF03471    PF00999    PF02080   
KEGG: vch:VC2703   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005488 F:binding
GO:0003824 F:catalytic activity
GO:0015299 F:solute:hydrogen antiporter activity
GO:0006884 P:cell volume homeostasis
GO:0008152 P:metabolic process
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.”  Heidelberg J.F.et.al.   10952301

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDAVTINSFF MIGALLIGIS VLLSPVSSKL GIPILLVFLA VGMLAGEDGI GQIAFDNYPV 
61:	AYLVSNLALA IILLDGGMRT RVASFRVAFW PSVSLATLGV AVTTLLTGLL AMWLFNLSLL 
121:	QGVLVGAIVG STDAAAVFSL LKGRSLNERV GATLEIESGT NDPMAVFLTV TLIAVLGSAE 
181:	TNLSAGFLLL SFIQQFGVGA LLGLAGGWIL WWLINRNQLP EGLYSILAVS GGLMIFALSN 
241:	ALGGSGILSI YLTGLLLGNR PTRSRHAILN VLDGMTWLAQ IGMFLVLGLL VTPSELMEIA 
301:	LPGLALAVGM ILFARPIAVW IGLAPFKSFT AREKWFVSWV GLRGAVPIIL AVFPMMAGLP 
361:	NAQLYFNLAF FVVMVSLVVQ GGTLTKAMSL AKVELPPKPE PISRTGVEIY PTSEWELFIY 
421:	KLKADKWCIG EPLRNLFMPE GTRIAAVFRD NQLLHPSGST ELCEGDTLCV MAQERDLESL 
481:	SRLFSEAPEK ASLARFFGDF FLDIEAKLQD VALLYGLDLG ELEADAKLKD LVLEHLGETP 
541:	VLGDYFEWHG LQWVVADVVD WKVTKIGLRL PPEEELQEGA E