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2.A.36.6.9
Na+/H+ antiporter, NhaP, of 443 aas.  Several 3-d structures are known (Wöhlert et al. 2014).  The ion is coordinated by three acidic side chains, a water molecule, a serine and a main-chain carbonyl in an unwound stretch of TMS 5 at the deepest point of a negatively charged cytoplasmic funnel. A second narrow polar channel may facilitate proton uptake from the cytoplasm. Transport activity is cooperative at pH 6 but not at pH 5, due to pH-dependent allosteric coupling of protomers through two histidines at the dimer interface (Wöhlert et al. 2014).

Accession Number:Q9UZ55
Protein Name:Na+/H+ antiporter, putative
Length:443
Molecular Weight:49188.00
Species:Pyrococcus abyssi (strain GE5 / Orsay) [272844]
Number of TMSs:13
Substrate Na+, H+

Cross database links:

Structure:
4CZ8   4CZ9   4CZA     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MIELSLAEAL FLILFTGVIS MLISRRTGIS YVPIFILTGL VIGPLLKLIP RDLAHEIFDF 
61:	VRVFGLVIIL FTEGHNLSWR LLKKNMPTIV TLDTIGLILT ALIAGFIFKV VFNSSFLLGF 
121:	LFGAIIGATD PATLIPLFRQ YRVKQDIETV IVTESIFNDP LGIVLTLIAI SMLVPGYGGG 
181:	IFSTLSEKLG IYAGGVIYFL YNVSVSISLG IFLGILGYKF IKRTGIFDFP EIEAFSLSLA 
241:	FLGFFIGERL DASGYLVATV TGIVLGNYKL LKPRENIRIL KRLQRAIEKE VHFNDTLAAL 
301:	ATIFIFVLLG AEMNLEVIWS NLGKGLLVAL GVMILARPLA TLPLLKWWNF REYLFIALEG 
361:	PRGVVPSALA SLPLSLALKY KSPLLTVHWG EIIMATVVIT VLTSVIVETL WIPILKDKLD 
421:	VGETIKERIE EKEEEKERRK VRG