TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.36.7.1
ApNhaP: a Na+:H+ antiporter at pH 5-9; a Ca2+:H+ antiporter at alkaline pH (not an Li:H+ antiporter) (Waditee et al. 2001).  When the gene for ApNhaP is expressed in the fresh water cyanobacterium, Synechococcus sp. PCC 7942, it became salt tolerant and could live in salt water (Waditee et al. 2002; ).

Accession Number:Q93HU4
Protein Name:ApNhaP
Length:521
Molecular Weight:56884.00
Species:Aphanothece halophytica [72020]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Golgi apparatus1 / Multi-pass membrane protein2
Substrate Na+, Ca 2+, H+

Cross database links:

Pfam: PF00999   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015299 F:solute:hydrogen antiporter activity
GO:0006812 P:cation transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Halotolerant cyanobacterium Aphanothece halophytica contains an Na(+)/H(+) antiporter, homologous to eukaryotic ones, with novel ion specificity affected by C-terminal tail.”  Waditee R.et.al.   11479290

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MTIEAAMGEE AIKENLEQFL IVLSVSLGVA TLSQISSFFR QIPYTLLLVI VGLGLAFVDI 
61:	RLVNLSPELI LEIFLPPLLF EAAWNIRWRN LKKNLFPVVL LAIIGVVISV VGIGFSLNYF 
121:	SGLSLPIALL VGAILAATDP VSVIALFREL GVGERLTVLM EGESLFNDGV AVVAFSLLVG 
181:	IPLGTQEFSV TNTLIQFVTL QGIGIGCGGV IGFGISYLTQ RFDLPLVEQS LTLVSAYGTY 
241:	LITEELGGSG VIGVVTVGLI LGNFGSRIGM NPRTRLLVSE FWEFIAFFVN SIVFLLIGDQ 
301:	INIRGLADNG QLILITIIAL VIIRAISIYG LGTISNLITK QDISWQEETV LWWGGLRGSV 
361:	SIALALSVPV MLDGRQDIIE AVFGVVLFTL LVQGLTMQTV IEKLGLIGDR AQRRTYSELI 
421:	ARRSALERVL AHLNAVPPSP SIRMKSLKTT KEASKGQLES RQTKKLRSYN NSYPQLRSLE 
481:	QEQLRELTFK VEADTYAELI RAGKLNNNLS PLLQEVLAKP E