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2.A.36.7.4
Sodium/hydrogen exchanger 11 (Na(+)/H(+) exchanger 11) (NHE-11) (Solute carrier family 9 member 11) (Solute carrier family 9 member C2)

Accession Number:Q5TAH2
Protein Name:Sodium/hydrogen exchanger 11
Length:1124
Molecular Weight:129053.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Genevestigator: Q5TAH2
eggNOG: NOG126655
HEGENOM: HOG000154241
Entrez Gene ID: 284525   
Pfam: PF00027    PF00520    PF00999   
KEGG: hsa:284525   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity
GO:0015299 F:solute:hydrogen antiporter activity
GO:0006814 P:sodium ion transport

References (2)

[1] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSSYFWAQNE SNRPDLLCGQ PADYLVEEKH FTTLVCFIVV LGGLLKMCLK NCEVIVLTIL 
61:	SLSGFVIGHM AYNSVEVHQI VYPLLRTSSF SLYSYFSPLI IFMVALDVEF YTLKKMFWQV 
121:	LLTGLISFST ASIIIGYVVI KFNKDSWDLQ SCLLFSITLG IIDPLRSVNS LKTIGISKIY 
181:	IDLIRGESLI ICSIASIFFG NFRGNRIHFS IFRDLHVGIE LSYDILGSII FGYWCAKIIQ 
241:	CILADVFSNM LTNIILCFSM VYMTFYIVEF LGMSGTLALA AVGLNLDSLT FKPKIELVIT 
301:	KFLRIFSSVY EHLIYAFFGI VIGCGELSHY EFHTIPFIFI LFTTVNLVRL LTILLVSPIL 
361:	MHSNYEYNWR WGVVITWSGI KGVFNLLWAP DVYNLAERKV EVPQMFILYV QVISLLTMGI 
421:	NSYVMTQSAR KLDLCVLSLP RQMILQNATQ HIQEIVQNTI TLFKTEKILT NVNWTLVEDK 
481:	TRIEYIPFSH VSHNDMKTES TTDEALMEEA RLHVAAIQMS SFEKQRNNGI LEIEAARILI 
541:	GAAKCYYSIQ GKFMSIYDVS TYMRTRSWLI KFKNVLTFLE YCIEKIHFIP PESNTFLTFI 
601:	FHIVFSEEFE YTGQIINLIY IYPMIIHLWP MARGLNVSAL ISINYYFMFL YVLESTLKII 
661:	ILKRKYFQQC WNTLEFFILV IGIIDIFCVY FVKLRPDNLA LIQLTVIMGY LRIIRFLPLF 
721:	KIIVPILIRI ADVQIKKRLS LMYSITKGYI KSQEDAKLLI KQIAVCESIY QKLCEILETN 
781:	KQDAVKELVL MEHEGRDVVI ALKTKQAIRN VIAKALKNLT FLCSRGIIDK HEVIEINKVL 
841:	LKKLKALNNF PKAIPPPTPD IYLHNIIWLE GKDVLIDFFK ERAKLACFDS GDTICKGGEM 
901:	PQGIYLIISG MAILHSLSPT FGIESNQRCD RGSRDMFTEF CTTGDIIGEL SCLLKREIEY 
961:	TVICETSLQA CFISLEDLYE GFDAFWPSLE YKIWLKLALS TAYQYFESSL IDEDLRFQNC 
1021:	VMFNQAYVET LSSYSDMIID NMTMKFVIIV YGSVIDTKTE EPYFAPCIIP TTCEQVQGTS 
1081:	DLSKLLIIQA SELTQRNSNT NVMASVNTVF EQPGKNINGR QKMS