TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.36.7.5
Sodium/hydrogen exchanger 10 (Na+/H+ exchanger 10) (NHE-10) (Solute carrier family 9 member 10) (Solute carrier family 9 member C1) (Sperm-specific Na+/H+ exchanger) (sNHE).  Predicted to have 17 TMSs in a 13 +  4 TMS arrangement.  The last 4 TMSs are homologous to the 4 TMS voltage sensor of the Ca2+ channel, 1.A.1.11.7.

Accession Number:Q4G0N8
Protein Name:Sodium/hydrogen exchanger 10
Length:1177
Molecular Weight:135206.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Cell projection1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Genevestigator: Q4G0N8
eggNOG: NOG126655
HEGENOM: HOG000169764
Entrez Gene ID: 285335   
Pfam: PF00027    PF00999   
KEGG: hsa:285335   

Gene Ontology

GO:0005929 C:cilium
GO:0020017 C:flagellar membrane
GO:0016021 C:integral to membrane
GO:0015299 F:solute:hydrogen antiporter activity
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0006814 P:sodium ion transport
GO:0030317 P:sperm motility
GO:0007283 P:spermatogenesis

References (3)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs.”  Oduru S.et.al.   12783626

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAGIFKEFFF STEDLPEVIL TLSLISSIGA FLNRHLEDFP IPVPVILFLL GCSFEVLSFT 
61:	SSQVQRYANA IQWMSPDLFF RIFTPVVFFT TAFDMDTYML QKLFWQILLI SIPGFLVNYI 
121:	LVLWHLASVN QLLLKPTQWL LFSAILVSSD PMLTAAAIRD LGLSRSLISL INGESLMTSV 
181:	ISLITFTSIM DFDQRLQSKR NHTLAEEIVG GICSYIIASF LFGILSSKLI QFWMSTVFGD 
241:	DVNHISLIFS ILYLIFYICE LVGMSGIFTL AIVGLLLNST SFKAAIEETL LLEFWTFLSR 
301:	IAFLMVFTFF GLLIPAHTYL YIEFVDIYYS LNIYLTLIVL RFLTLLLISP VLSRVGHEFS 
361:	WRWIFIMVCS EMKGMPNINM ALLLAYSDLY FGSDKEKSQI LFHGVLVCLI TLVVNRFILP 
421:	VAVTILGLRD ATSTKYKSVC CTFQHFQELT KSAASALKFD KDLANADWNM IEKAITLENP 
481:	YMLNEEETTE HQKVKCPHCN KEIDEIFNTE AMELANRRLL SAQIASYQRQ YRNEILSQSA 
541:	VQVLVGAAES FGEKKGKCMS LDTIKNYSES QKTVTFARKL LLNWVYNTRK EKEGPSKYFF 
601:	FRICHTIVFT EEFEHVGYLV ILMNIFPFII SWISQLNVIY HSELKHTNYC FLTLYILEAL 
661:	LKIAAMRKDF FSHAWNIFEL AITLIGILHV ILIEIDTIKY IFNETEVIVF IKVVQFFRIL 
721:	RIFKLIAPKL LQIIDKRMSH QKTFWYGILK GYVQGEADIM TIIDQITSSK QIKQMLLKQV 
781:	IRNMEHAIKE LGYLEYDHPE IAVTVKTKEE INVMLNMATE ILKAFGLKGI ISKTEGAGIN 
841:	KLIMAKKKEV LDSQSIIRPL TVEEVLYHIP WLDKNKDYIN FIQEKAKVVT FDCGNDIFEE 
901:	GDEPKGIYII ISGMVKLEKS KPGLGIDQMV ESKEKDFPII DTDYMLSGEI IGEINCLTNE 
961:	PMKYSATCKT VVETCFIPKT HLYDAFEQCS PLIKQKMWLK LGLAITARKI REHLSYEDWN 
1021:	YNMQLKLSNI YVVDIPMSTK TDIYDENLIY VILIHGAVED CLLRKTYRAP FLIPITCHQI 
1081:	QSIEDFTKVV IIQTPINMKT FRRNIRKFVP KHKSYLTPGL IGSVGTLEEG IQEERNVKED 
1141:	GAHSAATARS PQPCSLLGTK FNCKESPRIN LRKVRKE