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2.A.37.1.11
Transmembrane and coiled-coil domain 3,TMCO3 of 677 aas and 13 TMSs.  When mutated causes cornea guttata and anterior polar cataracts.  he encoding gene is expressed in the human cornea, lens capsule, and choroid-retinal pigment epithelium (Chen et al. 2016).

Accession Number:Q6UWJ1
Protein Name:Transmembrane and coiled-coil domain-containing protein 3
Length:677
Molecular Weight:75598.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKVLGRSFFW VLFPVLPWAV QAVEHEEVAQ RVIKLHRGRG VAAMQSRQWV RDSCRKLSGL 
61:	LRQKNAVLNK LKTAIGAVEK DVGLSDEEKL FQVHTFEIFQ KELNESENSV FQAVYGLQRA 
121:	LQGDYKDVVN MKESSRQRLE ALREAAIKEE TEYMELLAAE KHQVEALKNM QHQNQSLSML 
181:	DEILEDVRKA ADRLEEEIEE HAFDDNKSVK GVNFEAVLRV EEEEANSKQN ITKREVEDDL 
241:	GLSMLIDSQN NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTA IGLPTMFGYI 
301:	ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWKI SLQGPCYMTL 
361:	LMIAFGLLWG HLLRIKPTQS VFISTCLSLS STPLVSRFLM GSARGDKEGD IDYSTVLLGM 
421:	LVTQDVQLGL FMAVMPTLIQ AGASASSSIV VEVLRILVLI GQILFSLAAV FLLCLVIKKY 
481:	LIGPYYRKLH MESKGNKEIL ILGISAFIFL MLTVTELLDV SMELGCFLAG ALVSSQGPVV 
541:	TEEIATSIEP IRDFLAIVFF ASIGLHVFPT FVAYELTVLV FLTLSVVVMK FLLAALVLSL 
601:	ILPRSSQYIK WIVSAGLAQV SEFSFVLGSR ARRAGVISRE VYLLILSVTT LSLLLAPVLW 
661:	RAAITRCVPR PERRSSL