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2.A.39.1.1
Cytosine permease

Accession Number:P0AA82
Protein Name:Cytosine permease CodB aka B0336
Length:419
Molecular Weight:43650.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Cytosine

Cross database links:

Genevestigator: P0AA82
EchoBASE: EB1303
EcoGene: EG11327
eggNOG: COG1457
HEGENOM: HBG371811
RefSeq: AP_000988.1    NP_414870.1   
Entrez Gene ID: 944994   
Pfam: PF02133   
BioCyc: EcoCyc:CODB-MONOMER    ECOL168927:B0336-MONOMER   
KEGG: ecj:JW0327    eco:b0336   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0019858 P:cytosine metabolic process
GO:0015931 P:nucleobase, nucleoside, nucleotide and nucl...
GO:0055085 P:transmembrane transport

References (4)

[1] “Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase.”  Danielsen S.et.al.   1640834
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSQDNNFSQG PVPQSARKGV LALTFVMLGL TFFSASMWTG GTLGTGLSYH DFFLAVLIGN 
61:	LLLGIYTSFL GYIGAKTGLT THLLARFSFG VKGSWLPSLL LGGTQVGWFG VGVAMFAIPV 
121:	GKATGLDINL LIAVSGLLMT VTVFFGISAL TVLSVIAVPA IACLGGYSVW LAVNGMGGLD 
181:	ALKAVVPAQP LDFNVALALV VGSFISAGTL TADFVRFGRN AKLAVLVAMV AFFLGNSLMF 
241:	IFGAAGAAAL GMADISDVMI AQGLLLPAIV VLGLNIWTTN DNALYASGLG FANITGMSSK 
301:	TLSVINGIIG TVCALWLYNN FVGWLTFLSA AIPPVGGVII ADYLMNRRRY EHFATTRMMS 
361:	VNWVAILAVA LGIAAGHWLP GIVPVNAVLG GALSYLILNP ILNRKTTAAM THVEANSVE