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2.A.39.1.3
The putative hydroxymethylpyrimidine porter, CytX (Rodionov et al., 2002

Accession Number:A1KWE6
Protein Name:Putative permease
Length:407
Molecular Weight:42338.00
Species:neisseria meningitidis serogroup c / serotype 2a (strain atcc 700532 / fam18) [272831]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Hydroxymethylpyrimidine

Cross database links:

eggNOG: COG1457
HEGENOM: HBG422122
RefSeq: YP_975970.1   
Entrez Gene ID: 4674865   
Pfam: PF02133   
KEGG: nmc:NMC2048   

Gene Ontology

GO:0016020 C:membrane
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0015931 P:nucleobase, nucleoside, nucleotide and nucl...
GO:0055085 P:transmembrane transport

References (1)

[1] “Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18.”  Bentley S.D.et.al.   17305430

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSGNASSPSS SAAIGLIWFG AAVSIAEIST GTLLAPLGWQ RGLAALLLGH AVGGALFFAA 
61:	AYIGALTGRS SMESVRLSFG KRGSVLFSVA NMLQLAGWTA VMIYAGATVS SALGKVLWDG 
121:	ESFVWWALAN GALIVLWLVF GARKTGGLKT VSMLLMLLAV LWLSAEVFST AGSTAAQVSD 
181:	GMSFGTAVEL SAVMPLSWLP LAADYTRQAR RPFAATLTAT LAYTLTGCWM YALGLAAALF 
241:	TGETDVAKIL LGAGLGAAGI LAVVLSTVTT TFLDAYSAGV SANNISAKLS ETPIAVAVAV 
301:	VGTLLAVLLP VTEYENFLLL IGSVFAPMAA VLIADFFVLK RREEIEGFDF AGLVLWLAGF 
361:	ILYRFLLSSG WESSIGLTAP VMSAVAIATV SVRLFFKKTQ SLQRNPS