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2.A.39.2.1
Cytosine-purine permease

Accession Number:P17064
Protein Name:Fcy2 aka YER056C
Length:533
Molecular Weight:58201.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Purine-cytosine

Cross database links:

Genevestigator: P17064
eggNOG: fuNOG05221
HEGENOM: HBG396658
DIP: DIP-7593N
RefSeq: NP_010976.1   
Entrez Gene ID: 856783   
Pfam: PF02133   
KEGG: sce:YER056C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015212 F:cytidine transmembrane transporter activity
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0005515 F:protein binding
GO:0015861 P:cytidine transport
GO:0015856 P:cytosine transport
GO:0006863 P:purine transport
GO:0055085 P:transmembrane transport

References (7)

[1] “The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product.”  Weber E.et.al.   2191181
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.”  Dietrich F.S.et.al.   9169868
[3] “Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae.”  Hinnebusch A.G.et.al.   6300123
[4] “The immunodetected yeast purine-cytosine permease is not N-linked glycosylated, nor are glycosylation sequences required to have a functional permease.”  Rodriguez C.et.al.   7762297
[5] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[6] “Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.”  Gruhler A.et.al.   15665377
[7] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLEEGNNVYE IQDLEKRSPV IGSSLENEKK VAASETFTAT SEDDQQYIVE SSEATKLSWF 
61:	HKFFASLNAE TKGVEPVTED EKTDDSILNA ASMWFSANMV IASYALGALG PMVFGLNFGQ 
121:	SVLVIIFFNI MGLIFVAFFS VFGAELGLRQ MILSRYLVGN VTARIFSLIN VIACVGWGIV 
181:	NTSVSAQLLN MVNEGSGHVC PIWAGCLIII GGTVLVTFFG YSVIHAYEKW SWVPNFAVFL 
241:	VIIAQLSRSG KFKGGEWVGG ATTAGSVLSF GSSIFGFAAG WTTYAADYTV YMPKSTNKYK 
301:	IFFSLVAGLA FPLFFTMILG AASAMAALND PTWKAYYDKN AMGGVIYAIL VPNSLNGFGQ 
361:	FCCVLLALST IANNIPNMYT VALSAQALWA PLAKIPRVVW TMAGNAATLG ISIPATYYFD 
421:	GFMENFMDSI GYYLAIYIAI SCSEHFFYRR SFSAYNIDDW DNWEHLPIGI AGTAALIVGA 
481:	FGVALGMCQT YWVGEIGRLI GKYGGDIGFE LGASWAFIIY NILRPLELKY FGR