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2.A.39.2.4
The cytosine-purine-scavenging protein, FcyB (low capacity, high affinity; 45% identical and maybe orthologous to the yeast purine-cytosine protein (2.A.39.2.3) (Vlanti and Diallinas 2008).  Substrate docking and mutational analyses have revealed residues essential for specificity and function (Krypotou et al. 2012). The substrate specificities and phylogenies of members of the NCS1 family have been reported (Krypotou et al. 2015).

Accession Number:B1PXD0
Protein Name:Cytosine-purine permease
Length:508
Molecular Weight:55197.00
Species:Emericella nidulans [162425]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Purine-cytosine

Cross database links:

Pfam: PF02133   

Gene Ontology

GO:0016020 C:membrane
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0015931 P:nucleobase, nucleoside, nucleotide and nucl...
GO:0055085 P:transmembrane transport

References (1)

[1] “The Aspergillus nidulans FcyB cytosine-purine scavenger is highly expressed during germination and in reproductive compartments and is downregulated by endocytosis.”  Vlanti A.et.al.   18384518

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGAFDFDLE KNPPVVQSTA DNSSDGAVPG ETFTYGDSTY AKIQRLAAEL NIEQRGIERV 
61:	PAAEQTDTSV FNIGSMWLAA NMVVSSFAIG VLGKSVYSLG FVDAILTVLF FNLLGIMTVC 
121:	FFSCFGPFGL RQMVFSRLWF GWYVTKGFAV LNILACLGWS AANAIVGAQM LHAVNSDVPG 
181:	FAAILIISIC TLLVTFAGYK VVHLYEYWSW IPTFIVFMII LGTFAHSGDF QNIPMGVGTS 
241:	EMGSVLSFGS AVYGFATGWT SYAADYTVYQ PANRSKRKIF LSTWLGLIVP LLFVEMLGVA 
301:	VMTATDIKGS KYDVGYATSG NGGLIAAVLQ PLGGFGDFCL VILALSIVAN NCPNFYSVAL 
361:	TVQVLSRYAQ RVPRFIWTLF GTGVSIAIAI PGYSHFETVL ENFMNFIAYW LAIYSAIAIM 
421:	DHFVFKRGFS GYVVENFDKR EKLPVGIAAT IAFGFGVAGM ITGMSQPWYV GPIARHAAGG 
481:	DVGFELGFAF AAFSYLCLRP FEIKFFGR