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2.A.39.3.12
NCS1 of 540 aas and 12 TMSs.  Transports adenine, guanine, hypoxanthine, cytosine, and allantoin and competitively binds xanthine and uric acid. The closely related Zea mays NCS1 transports adenine, guanine, and cytosine and competitively binds, 5-fluorocytosine, hypoxanthine, xanthine, and uric acid. The differences in these NCS1 profiles are due to a limited number of amino acid differences (Rapp et al. 2016).

Accession Number:V9SBV7
Protein Name:Nucleobase cation symporter 1
Length:540
Molecular Weight:56930.00
Species:Setaria viridis (Green bristlegrass) [4556]
Number of TMSs:12
Substrate Adenine, guanine, Hypoxanthine, Cytosine, Allantoin, Xanthine, Uric acid, 5-fluorocytosine

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External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAMSMAMSKA ITARHATHLQ HRLVASSSQA APRLPLLPRR PSLALTVASP PRRLLPASPR 
61:	SSSSESDLAP TPPSERTMTA WDLASLWVGL VVGVPSYYLA GSLVDLGMSA LQGVATVAFA 
121:	NLIVLVTLVL TAAPAVTHGL PFPVLARAAF GVRGAHVPAV IRALVGCGWF GIESWIGGRA 
181:	IFLLLPSRLK SYQPLLAPVP GLGAAPLEFA CFLAFWAAQL GVIMRGMEGI RKLEKFAAPV 
241:	LFVLTSALLA WAYTSAGGFG RILSLPPRLT GAEFRKVFFP SLTANISFWA TVAINIPDFA 
301:	RYARSQADQV LGQAGLPVFM GMFTFAGLAI TSATEAIFGH VVSDPIELLG RIGGPVTTFL 
361:	AIFGIGLATI TTNIAANVVA PANALVSMSP RRFTFAKGAL VTALLGIAFQ PWRLLSSSES 
421:	FVYTWLLGYS ALMGPIGGVI LADHYIVRRT ALDVDALYSE DSGSPYYFQN GFNVAAMAAM 
481:	AAGVAPIVPG FLQKVGVLPS VSKAFATAYN NAWFVSFFVA GAVYCLLCGR GGVQAKQHSN