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2.A.39.3.13
Uracil-specific permease of 581 aas and 11 or 12 TMSs. FUR4.  Deletion of the FUR4 gene confers resistance to 5-fluorouracil as well as cross-resistance to triazoles and imidazole antifungal agents when they are used simultaneously with 5-fluorouracil although the nucleobase transporters are not involved in azole uptake. Only fluorinated pyrimidines, not pyrimidines themselves, are able to promote cross-resistance to azoles by both the salvage and the de novo pathway of pyrimidine synthesis. Subinhibitory doses of 5-fluorocytosine, 5-fluorouracil, and 5-fluorouridine also trigger resistance to fluconazole in susceptible wild-type strains of C. lusitaniae and of different Candida species. Thus, intracellular fluorinated nucleotides play a role in azole resistance, either by preventing azoles from targeting the catalytic site of lanosterol 14-alpha-demethylase or by acting as a molecular switch for the triggering of efflux transport (Gabriel et al. 2014; ).

Accession Number:R9WAS9
Protein Name:Uracil permease
Length:581
Molecular Weight:64936.00
Species:Clavispora lusitaniae [36911]
Number of TMSs:11
Substrate Uracil

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FASTA formatted sequence
1:	MSSATKGYDD TFTKSESDSQ SVTSVVDEKP SLWQRINKKI SLQNPDLSLV QNFLINDDLK 
61:	PLLNPQDRTW RWFHFIFFWI SDSYNINTWQ IAGTGVEAGL SWWEVWISVI LGYSFVGLFI 
121:	FLAQRVGAYY HVSFPVSCRA SFGIFGSLWP IINRVVMAVV WASVQSWIGG QCVQLMLMSI 
181:	FGADLDTKIP NKIKGSGTTS FQFLCFFLFC FFSLPAIYLK PQKLRHLFTM KAIVSPACGI 
241:	ALLIWTIKRA GGIGPVVHQK TSVSGSTHAW AFINSTMNCI ANFATLTLNA PDFSRLAKTR 
301:	HSSSWTQAIS IPLSFALTAI IGILVSSASK VMYGTAYWSP LDVMKEYVMS YTSGDRGGVF 
361:	IIALGFAIAQ LGTNISANYI SAGTDMTALL PQYINIRRGG FIAAAICFTI CPWHFFSSSK 
421:	NFTTYLSAYA VFLSAITGVI ASDYFWVRRG YLNVWHLYSF TPESNYSYNS LGVNWRAYVA 
481:	YICGILPNIV GFVGACGVSI PIGAQYVYNL SYFAGYIVSF TIYALFCFFW PVKGAPVKDI 
541:	REKGWYEVYV EDRPGEKFSD IVSGKLEENE YVRARGGIRL L