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2.A.39.3.3
Uridine (nucleoside; fluorouridine; not uracil or allantoin) permease, Fui1 (Uridine:H+ (1:1) symporter) (inhibited by analogues with modifications at positions C5') (Zhang et al., 2006)

Accession Number:P38196
Protein Name:Fui1 aka YBL042 aka YBC2 aka YBL042C aka YBL0406
Length:639
Molecular Weight:72165.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Uridine, Fluorouridine, H+

Cross database links:

Genevestigator: P38196
eggNOG: fuNOG07992
HEGENOM: HBG333533
DIP: DIP-1321N
RefSeq: NP_009511.1   
Entrez Gene ID: 852238   
Pfam: PF02133   
KEGG: sce:YBL042C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0005515 F:protein binding
GO:0015213 F:uridine transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0015862 P:uridine transport

References (7)

[1] “The sequence of a 22.4 kb DNA fragment from the left arm of yeast chromosome II reveals homologues to bacterial proline synthetase and murine alpha-adaptin, as well as a new permease and a DNA-binding protein.”  de Wergifosse P.et.al.   7871888
[2] “Complete DNA sequence of yeast chromosome II.”  Feldmann H.et.al.   7813418
[3] “The ORF YBL042 of Saccharomyces cerevisiae encodes a uridine permease.”  Wagner R.et.al.   9485596
[4] “Nucleoside transporter proteins of Saccharomyces cerevisiae. Demonstration of a transporter (FUI1) with high uridine selectivity in plasma membranes and a transporter (FUN26) with broad nucleoside selectivity in intracellular membranes.”  Vickers M.F.et.al.   10827169
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[6] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[7] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPVSDSGFDN SSKTMKDDTI PTEDYEEITK ESEMGDATKI TSKIDANVIE KKDTDSENNI 
61:	TIAQDDEKVS WLQRVVEFFE VKNDSTDLAD HKPENPIRTF KDLQESLRST YLYNTDLRPV 
121:	EAKRRTWTWK QYIFFWISGS FNVNTWQISA TGLQLGLNWW QTWICIWVGY TFVAFFLILG 
181:	SKVGNNYHIS FPISSRVSFG IYFSIWIVIN RVVMACVWNS TLAYIGSQCV QLMLKAIFGT 
241:	NLNTRIKDTI KNPNLTNFEF MCFMVFWVAC LPFLWFPPDK LRHIFALKSA ITPFAAFGFL 
301:	IWTLCKAKGH LALGSLNDNG GAISKTVLAW SVIRAIMSAL DNFSTLILNA PDFTRFGKTY 
361:	KSSVYSQLIA LPVCYAIISL IGILSVSAAY TLYGVNYWSP LDILNRYLDN YTSGNRAGVF 
421:	LISFIFAFDQ LGANLSGNSI PAGTDLTALL PKFINIRRGS YICALISLAI CPWDLLSSSS 
481:	KFTTALAAYA VFLSAIAGVI SADYFIVRKG YVNIFHCYTD KPGSYYMYNK YGTNWRAVVA 
541:	YIFGIAPNFA GFLGSVGVSV PIGAMKVYYL NYFVGYLLAA LSYCILVYFY PIKGIPGDAK 
601:	ITDRKWLEEW VEVEEFGTER EAFEEYGGVS TGYEKIRYI