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2.A.4.2.2
Vacuolar Zn2+, Cd2+ uptake (into vacuoles) permease (Zn2+/Cd2+:H+ antiporter). A single mutation (N44I) changes the specificity from Zn2+ to Fe2+ (Lin et al., 2008). Lin et al. (2009) have identified transmembrane residues that determine metal specificity.

Accession Number:P20107
Protein Name:ZRC1 aka ZnrP aka YMR243C aka YM9408.05C
Length:442
Molecular Weight:48345.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate Zn2+, Cd2+, H+

Cross database links:

Genevestigator: P20107
eggNOG: fuNOG05089
HEGENOM: HBG317426
DIP: DIP-2030N
RefSeq: NP_013970.1   
Entrez Gene ID: 855284   
Pfam: PF01545   
KEGG: sce:YMR243C   

Gene Ontology

GO:0000324 C:fungal-type vacuole
GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis
GO:0006824 P:cobalt ion transport
GO:0006749 P:glutathione metabolic process
GO:0046686 P:response to cadmium ion
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (7)

[1] “Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae.”  Kamizono A.et.al.   2693940
[2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.”  Bowman S.et.al.   9169872
[3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[4] “Global analysis of protein expression in yeast.”  Ghaemmaghami S.et.al.   14562106
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[6] “Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.”  Li X.et.al.   17330950
[7] “Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.”  Smolka M.B.et.al.   17563356

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MITGKELRII SLLTLDTVFF LLEITIGYMS HSLALIADSF HMLNDIISLL VALWAVDVAK 
61:	NRGPDAKYTY GWKRAEILGA LINAVFLIAL CFSIMIEALQ RLIEPQEIQN PRLVLYVGVA 
121:	GLISNVVGLF LFHDHGSDSL HSHSHGSVES GNNDLDIESN ATHSHSHASL PNDNLAIDED 
181:	AISSPGPSGQ IGEVLPQSVV NRLSNESQPL LNHDDHDHSH ESKKPGHRSL NMHGVFLHVL 
241:	GDALGNIGVI AAALFIWKTE YSWRYYSDPI VSLIITIIIF SSALPLSRRA SRILLQATPS 
301:	TISADQIQRE ILAVPGVIAV HDFHVWNLTE SIYIASIHVQ IDCAPDKFMS SAKLIRKIFH 
361:	QHGIHSATVQ PEFVSGDVNE DIRRRFSIIA GGSPSSSQEA FDSHGNTEHG RKKRSPTAYG 
421:	ATTASSNCIV DDAVNCNTSN CL