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2.A.4.2.3
Plasma membrane Zn2+ efflux permease.  Substituing H43 with N (asn) changed the specificity from Zn2+ to Mn2+, and this difference was found in the Mn2+-specific metal ion exporter, ZnT10 (TC# 2.A.4.2.5) (Nishito et al. 2016). Expression on the cell surface is controlled by cellular zinc levels (Nishito and Kambe 2019).

Accession Number:Q62720
Protein Name:Znt1 aka SLC30A1
Length:507
Molecular Weight:55143.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q62720
eggNOG: roNOG13916
RefSeq: NP_074044.1   
Entrez Gene ID: 58976   
Pfam: PF01545   
KEGG: rno:58976   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030315 C:T-tubule
GO:0019855 F:calcium channel inhibitor activity
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0070574 P:cadmium ion transmembrane transport
GO:0070509 P:calcium ion import
GO:0046929 P:negative regulation of neurotransmitter sec...
GO:0006829 P:zinc ion transport

References (2)

[1] “Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc.”  Palmiter R.D.et.al.   7882967
[2] “Regulation of the zinc transporter ZnT-1 by dietary zinc.”  McMahon R.J.et.al.   9560190

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA LVVALVAERF 
61:	ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA VERFIEPHEM QQPLVVLSVG 
121:	VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH GHGHGHLAKG ARKAGRAGGE AGAPPGRAPD 
181:	QEPDQEETNT LVANTSNSNG LKADQAEPEK LRSDDPVDVQ VNGNLIQESD SLESEDNRAG 
241:	QLNMRGVFLH VLGDALGSVI VVVNALVFYF SWKGCTEDDF CVNPCFPDPC KSSVELMNST 
301:	QAPMHEAGPC WVLYLDPTLC IIMVCILLYT TYPLLKESAL ILLQTVPKQI DIKHLVKELR 
361:	DVEGVEEVHE LHVWQLAGSR IIATAHIKCE DPASYMQVAK TIKDVFHNHG IHATTIQPEF 
421:	ASVGSKSSVV PCELACRTQC ALKQCCGTRP QVHSGKEAEK APTVSISCLE LSENLEKKPR 
481:	RTKAEGSVPA VVIEIKNVPN KQPESSL