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2.A.4.2.4
Zn2+ exporter, CDF-1

Accession Number:Q95QW4
Protein Name:Cation diffusion facilitator family protein 1
Length:561
Molecular Weight:61434.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

eggNOG: meNOG08266
HEGENOM: HBG388352
RefSeq: NP_509095.1    NP_509096.1   
Entrez Gene ID: 180923   
Pfam: PF01545   
KEGG: cel:C15B12.7   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0008324 F:cation transmembrane transporter activity
GO:0019915 P:lipid storage
GO:0007275 P:multicellular organismal development
GO:0040010 P:positive regulation of growth rate
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (3)

[1] “Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling.”  Bruinsma J.J.et.al.   12015965
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “Cation diffusion facilitator proteins modulate Raf-1 activity.”  Jirakulaporn T.et.al.   15096503

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEVTMEDRSV KADKADRDDN NTTSTELLGK MRQTKVISTN QNNNHLIDRM VSIYEMEMIK 
61:	SQSTETISDV SDVLEFTVID NCSHGTHTLE HDLRLKGEPI GKSESVKGVS RSLIIQIGMT 
121:	VIFCALEFIT GVVCSSIAML ADSYHMAADV MALIVAFTCI KIATRPSTRL GYGWVRAETL 
181:	GGFFNGIFMC TVCVLVFQEA VGRIINVHMI THPLQVLVIG FIGLLINLFG MFNLSGHGHS 
241:	HGGGSHGHSH GGSHGHSHNN KKTKKNDGHG HSHANGHGHS HDGKSDCNGE EEPDHTRLNG 
301:	KFRSASAMAN SDANVRLLDN DDNSNDIIER RLSGVNSQNT IIATVDRQMT PYGTHMASEV 
361:	LNVSSNNLDK SAQKTEQKKD KNVNIHGVWL HLLSDAFGSV IVMISAGFVY FLPTWKIAAY 
421:	LDPILSISLA SIMGFTAVVL VKTSGEKLLK QTPEGLDLEK VKKDLCSIVG VSKVEKLSVW 
481:	TLCGQRIIAA AHVNICHPAV FPEAAYKIKN YFHDLGVHST TIEPTFEDTC MQSMRIMVKK 
541:	VVDGKSIEEP VSVSTENEIT E