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2.A.4.2.6
Zinc transporter 1 (ZnT-1) (Solute carrier family 30 member 1). The loss of the sialic acid transporter SLC35A1/CST (TC# 2.A.7.12.11) and the zinc transporter, ZnT1, affected cell survival upon infection with cytolytic vesicular stomatitis virus (VSV). Both of these transporters seem to play a role in the apoptotic response induced by VSV (Moskovskich et al. 2019).

Accession Number:Q9Y6M5
Protein Name:Zinc transporter 1
Length:507
Molecular Weight:55300.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q9Y6M5
eggNOG: COG1230
HEGENOM: HOG000166089
Entrez Gene ID: 7779   
Pfam: PF01545   
KEGG: hsa:7779   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030315 C:T-tubule
GO:0019855 F:calcium channel inhibitor activity
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0070574 P:cadmium ion transmembrane transport
GO:0070509 P:calcium ion import
GO:0006874 P:cellular calcium ion homeostasis
GO:0006882 P:cellular zinc ion homeostasis
GO:0071585 P:detoxification of cadmium ion
GO:0001701 P:in utero embryonic development
GO:0090281 P:negative regulation of calcium ion import
GO:0046929 P:negative regulation of neurotransmitter secretion
GO:0071584 P:negative regulation of zinc ion import
GO:0006829 P:zinc ion transport

References (2)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[2] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF 
61:	ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFIEPHEM QQPLVVLGVG 
121:	VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH GGHGHGHGLP KGPRVKSTRP GSSDINVAPG 
181:	EQGPDQEETN TLVANTSNSN GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA 
241:	GQLNMRGVFL HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS 
301:	THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ IDIRNLIKEL 
361:	RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA KTIKDVFHNH GIHATTIQPE 
421:	FASVGSKSSV VPCELACRTQ CALKQCCGTL PQAPSGKDAE KTPAVSISCL ELSNNLEKKP 
481:	RRTKAENIPA VVIEIKNMPN KQPESSL