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2.A.4.3.1
Vesicular Zn2+ uptake (into endosomal/lysosomal vesicles) permease, ZnT2. There are two isoforms due to alternative splicing, 35 kDa (plasma membrane localized) and 42 kDa (endosome/secretory compartment localized) (Lopez and Kelleher, 2009).

Accession Number:Q62941
Protein Name:Znt2 aka SLC30A2
Length:359
Molecular Weight:39277.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q62941
eggNOG: roNOG14886
RefSeq: NP_037022.1   
Entrez Gene ID: 25362   
Pfam: PF01545   

Gene Ontology

GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (1)

[1] “ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration.”  Palmiter R.D.et.al.   8617223

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASRSFFGAL WKSEASRIPP VNLPSVELAV QSNHYCHAQK DSGSHPNSEK QRARRKLYVA 
61:	SAICLVFMIG EIIGGYLAQS LAIMTDAAHL LTDFASMLIS LFSLWVSSRP ATKTMNFGWQ 
121:	RAEILGALLS VLSIWVVTGV LVYLAVQRLI SGDYEIKGDT MLITSGCAVA VNIIMGLALH 
181:	QSGHGHSHGH SHEDSSQQQQ NPSVRAAFIH VVGDLLQSVG VLVAAYIIYF KPEYKYVDPI 
241:	CTFLFSILVL GTTLTILRDV ILVLMEGTPK GVDFTTVKNL LLSVDGVEAL HSLHIWALTV 
301:	AQPVLSVHIA IAQNVDAQAV LKVARDRLQG KFNFHTMTIQ IESYSEDMKS CQECQGPSE