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2.A.4.3.3
Mammary epithelia/brain Zn2+ transporter ZnT4 (the cause of inherited zinc deficiency in the lethal milk (lm) syndrome of mice, due to a nonsense mutation at codon 297 (arg) in the ZnT4 gene) (Huang and Gitschier, 1997).

Accession Number:O35149
Protein Name:Zinc transporter 4 aka ZnT4
Length:430
Molecular Weight:47791.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: O35149
HEGENOM: HBG317426
Pfam: PF01545   

Gene Ontology

GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0055085 P:transmembrane transport
GO:0055069 P:zinc ion homeostasis
GO:0006829 P:zinc ion transport

References (1)

[1] “A novel gene involved in zinc transport is deficient in the lethal milk mouse.”  Huang L.et.al.   9354792

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGPGAWKRL KSLLRKDDTP LFLNDTSAFD FSDEVSDEGL SRFNKLRVVV ADDDSEAPER 
61:	PVNGAHPALQ ADDDSLLDQD LPLTNSQLSL KMDPCDNCSK RRELLKQRKV KTRLTIAAVL 
121:	YLLFMIGELV GGYMANSLAI MTDALHMLTD LSAIILTLLA LWLSSKSPTR RFTFGFHRLE 
181:	VLSAMISVML VYVLMGFLLY EAVQRTIHMN YEINGDVMLI TAAVGVAVNV IMGFLLNQSG 
241:	HHHSHAHSHS LPSNSPSMVS SGHNHGQDSL AVRAAFVHAL GDLVQSVGVL IAAYIIRFKP 
301:	EYKIADPICT YIFSLLVAFT TFRIIWDTVV IILEGVPSHL NVDYIKESLM KIEDVYSVED 
361:	LNIWSLTSGK STAIVHMQLI PGSSSKWEEV QSKAKHLLLN TFGMYKCTIQ LQSYRQEVIR 
421:	TCANCQSSST