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2.A.4.4.3
Golgi/secretory granule Zn2+ uptake (into Golgi or granules) permease, ZnT5 or ZTL1 (ZnT5 forms heterooligomers with ZnT6) (Ellis et al., 2005; Ishihara et al., 2006; Fukunaka et al. 2009) (Variant B catalyzes bidirectional transport (Valentine et al., 2007) )

Accession Number:Q8TAD4
Protein Name:Znt5
Length:765
Molecular Weight:84047.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Golgi apparatus1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

COG1230
Genevestigator: Q8TAD4 Q8TAD4
HEGENOM: HBG715462 HOG000018690
RefSeq: NP_075053.2   
Entrez Gene ID: 64924   
Pfam: PF01545   
OMIM: 607819  gene
KEGG: hsa:64924    hsa:64924   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005794 C:Golgi apparatus
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0030667 C:secretory granule membrane
GO:0008270 F:zinc ion binding
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis
GO:0006824 P:cobalt ion transport
GO:0010155 P:regulation of proton transport
GO:0010043 P:response to zinc ion
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0000139 C:Golgi membrane
GO:0005730 C:nucleolus

References (19)

[1] “Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.”  Kambe T.et.al.   11904301
[2] “A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.”  Cragg R.A.et.al.   11937503
[3] “Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.”  Devergnas S.et.al.   15276077
[4] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[6] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.”  Suzuki T.et.al.   15994300
[9] “Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.”  Suzuki T.et.al.   15525635
[10] “Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells.”  Kambe T.et.al.   11904301
[11] “A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane.”  Cragg R.A.et.al.   11937503
[12] “Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study.”  Devergnas S.et.al.   15276077
[13] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[14] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[15] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[16] “The DNA sequence and comparative analysis of human chromosome 5.”  Schmutz J.et.al.   15372022
[17] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[18] “Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.”  Suzuki T.et.al.   15994300
[19] “Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.”  Suzuki T.et.al.   15525635

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEEKYGGDVL AGPGGGGGLG PVDVPSARLT KYIVLLCFTK FLKAVGLFES YDLLKAVHIV 
61:	QFIFILKLGT AFFMVLFQKP FSSGKTITKH QWIKIFKHAV AGCIISLLWF FGLTLCGPLR 
121:	TLLLFEHSDI VVISLLSVLF TSSGGGPAKT RGAAFFIIAV ICLLLFDNDD LMAKMAEHPE 
181:	GHHDSALTHM LYTAIAFLGV ADHKGGVLLL VLALCCKVGF HTASRKLSVD VGGAKRLQAL 
241:	SHLVSVLLLC PWVIVLSVTT ESKVESWFSL IMPFATVIFF VMILDFYVDS ICSVKMEVSK 
301:	CARYGSFPIF ISALLFGNFW THPITDQLRA MNKAAHQEST EHVLSGGVVV SAIFFILSAN 
361:	ILSSPSKRGQ KGTLIGYSPE GTPLYNFMGD AFQHSSQSIP RFIKESLKQI LEESDSRQIF 
421:	YFLCLNLLFT FVELFYGVLT NSLGLISDGF HMLFDCSALV MGLFAALMSR WKATRIFSYG 
481:	YGRIEILSGF INGLFLIVIA FFVFMESVAR LIDPPELDTH MLTPVSVGGL IVNLIGICAF 
541:	SHAHSHAHGA SQGSCHSSDH SHSHHMHGHS DHGHGHSHGS AGGGMNANMR GVFLHVLADT 
601:	LGSIGVIVST VLIEQFGWFI ADPLCSLFIA ILIFLSVVPL IKDACQVLLL RLPPEYEKEL 
661:	HIALEKIQKI EGLISYRDPH FWRHSASIVA GTIHIQVTSD VLEQRIVQQV TGILKDAGVN 
721:	NLTIQVEKEA YFQHMSGLST GFHDVLAMTK QMESMKYCKD GTYIM