TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.4.8.3
Zn2+ transporter, TMEM163, of 289 aas and 6 TMSs.  Interacts with TrpML1 (TC# 1.A.5.3.1) to influence Zn2+ homeostasis, possibly by pumping out Zn2+.  May be involved in the human lipid storage disorder, mucolipidosis type IV (MLIV), caused by Zn2+ overload (Cuajungco et al. 2014). TMEM163 is found in synaptic vesicles where it is called SV31 (Burré et al. 2007). It plays a role in Zn2+ uptake into lysosomes (Cuajungco and Kiselyov 2017).

Accession Number:Q8TC26
Protein Name:Transmembrane protein 163
Length:289
Molecular Weight:31469.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cytoplasmic vesicle1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER QVRISESGQF 
61:	SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL ALAVAAFTVS VMRYSASAFG 
121:	FAFDAILDVL SSAIVLWRYS NAAAVHSAHR EYIACVILGV IFLLSSICIV VKAIHDLSTR 
181:	LLPEVDDFLF SVSILSGILC SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA 
241:	EVFKHDSAVW YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE