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2.A.40.4.2
The putative xanthine permease, YicE (Karatza and Frillingos, 2005)

Accession Number:P0AGM9
Protein Name:YicE
Length:463
Molecular Weight:48868.00
Species:Escherichia coli [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Xanthine

Cross database links:

Genevestigator: P0AGM9
EchoBASE: EB1180
EcoGene: EG11194
eggNOG: COG2233
HEGENOM: HBG470187
RefSeq: AP_004138.1    NP_418111.1   
Entrez Gene ID: 948172   
Pfam: PF00860   
BioCyc: EcoCyc:YICE-MONOMER    ECOL168927:B3654-MONOMER   
KEGG: ecj:JW3629    eco:b3654   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0042907 F:xanthine transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0042906 P:xanthine transport

References (4)

[1] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Characterization of the Escherichia coli K12 gltS glutamate permease gene.”  Kalman M.et.al.   2017136

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSVSTLESEN AQPVAQTQNS ELIYRLEDRP PLPQTLFAAC QHLLAMFVAV ITPALLICQA 
61:	LGLPAQDTQH IISMSLFASG VASIIQIKAW GPVGSGLLSI QGTSFNFVAP LIMGGTALKT 
121:	GGADVPTMMA ALFGTLMLAS CTEMVISRVL HLARRIITPL VSGVVVMIIG LSLIQVGLTS 
181:	IGGGYAAMSD NTFGAPKNLL LAGVVLALII LLNRQRNPYL RVASLVIAMA AGYALAWFMG 
241:	MLPESNEPMT QELIMVPTPL YYGLGIEWSL LLPLMLVFMI TSLETIGDIT ATSDVSEQPV 
301:	SGPLYMKRLK GGVLANGLNS FVSAVFNTFP NSCFGQNNGV IQLTGVASRY VGFVVALMLI 
361:	VLGLFPAVSG FVQHIPEPVL GGATLVMFGT IAASGVRIVS REPLNRRAIL IIALSLAVGL 
421:	GVSQQPLILQ FAPEWLKNLL SSGIAAGGIT AIVLNLIFPP EKQ