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2.A.40.4.4
Purine (uric acid and xanthine) permease, UapC.  Present in many Ascomycetes (Krypotou and Diallinas 2014).

Accession Number:P48777
Protein Name:UapC
Length:580
Molecular Weight:61349.00
Species:Emericella nidulans (Aspergillus nidulans) [162425]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Urate, Xanthine

Cross database links:

RefSeq: XP_664334.1   
Entrez Gene ID: 2870356   
Pfam: PF00860   
KEGG: ani:AN6730.2   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (2)

[1] “Genetic and molecular characterization of a gene encoding a wide specificity purine permease of Aspergillus nidulans reveals a novel family of transporters conserved in prokaryotes and eukaryotes.”  Diallinas G.et.al.   7721763
[2] “Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.”  Galagan J.E.et.al.   16372000

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDGPDQIGPD VRPRRTFGDR VRRAARAFTT RDGLIGDYDY GFLFTPRLPF VKQKRRAAPF 
61:	FGLEDKIPLV LALLLGLQHA LAMLAGVITP PILLAGSSGA NFGADESQYL VSTSLIVSGL 
121:	LSAVQMFRLH VYKTRYYVGT GLVSVVGTSF ATITVATGTF NQMYSTGYCP VDGSGNRLPC 
181:	PKGYGALLAT SCLCSLLEIG LSFMSSRLLK ALFPPIVTGP TVFLIGASLI GNAMKDWAGG 
241:	SGTCSSNPGN GALCPSADAP HPLPWGSAEF IGLGFLVFAT IILCERFGSP IMKSCAVIVG 
301:	LLVGCIVAAA CGYFDRSGID AAPVASFIWV KTFPLTIYAP LILPLLAVYM VIMMESIGDI 
361:	TATCDVSRLQ VEGATFDSRI QGGVLGNGIT CLLAGLCTIT PMSVFAQNNG VIALTRCANR 
421:	KAGYCCCFFL VVMGIFAKFA AALVAIPSSV LGGMTTFLFS SVAISGVRIM CSVDWTRRNR 
481:	FILTASFAVG MAATLVPDWF SYFFTYSGDN HALEGLLQAV ELVMANGFAV TGFLGLLLNL 
541:	ILPEDMEEDV VESEEDYEAT TVVGMQGGSE PGSSGQNVKA